Testing PSMA PET/MRI-guided prostate biopsy in men with a prior negative biopsy
Compares two biopsy methods for men with suspected prostate cancer and a prior negative biopsy.
Plain-language title generated from the registry record
Registry title: PSMA PET/MRI-Guided Prostate Biopsy for PI-RADS ≤3 and Prior Negative Biopsy
Key facts
- Where
- Fuzhou, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 30 and 85 years old?
Source: NCT06923657, who can take part
Where in China
- The First Affiliated Hospital of Fujian Medical UniversityFuzhou, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- First Affiliated Hospital of Fujian Medical University
- Trial code
- NCT06923657
- Record updated
- 28 May 2026
- Original description
The goal is to provide more accurate diagnostic tools and optimized diagnostic workflows for clinically suspected prostate cancer patients with prior negative biopsies, improving early detection rates for csPCa and reducing missed diagnoses.Read full original descriptionShow less
Application of PSMA PET/MRI-guided Prostate Targeted Biopsy in Patients With PI-RADS ≤ 3 and Negative Previous Biopsy: A Single-center, Prospective, Open-label, Randomized Controlled Trial
The goal is to provide more accurate diagnostic tools and optimized diagnostic workflows for clinically suspected prostate cancer patients with prior negative biopsies, improving early detection rates for csPCa and reducing missed diagnoses.
Inclusion: Serum PSA > 4 ng/mL; At least one prior negative prostate biopsy; At least two consecutive increases in PSA and/or PHI; Negative digital rectal examination; Multiparametric MRI (mpMRI) indicating a PI-RADS score ≤ 3.
Exclusion: Concurrent presence of other malignant tumors; Previous treatment with any form of anti-tumor therapy or prostate surgery (excluding prostate biopsy); Inability to comply with PSMA PET/MRI examination (e.g., contrast allergy, claustrophobia, etc.); Contraindications for prostate biopsy (e.g., coagulation disorders, acute prostatitis, acute urinary tract infection, etc.); Severe organ dysfunction (e.g., significant cardiac, pulmonary, hepatic, or renal impairment); Age ≤ 30 years or > 85 years; Incomplete clinical or pathological data.