Tests lidocaine infusion during colon cancer surgery against placebo
Tests a lidocaine drip given around surgery in people with colon cancer.
Plain-language title generated from the registry record
Registry title: Effect of Perioperative Intravenous Infusion of Lidocaine on the Postoperative Course and the Immune Response in Patients Undergoing Surgery for Colon Cancer - the PILDI Study
Key facts
- Where
- Ljubljana, SloveniaSee the site
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06923787, who can take part
Where in Slovenia
- Institute of Oncology LjubljanaLjubljana, SloveniaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Institute of Oncology Ljubljana
- Trial code
- NCT06923787EU 2025-521808-22-01
- Record updated
- 5 February 2026
- Original description
There are very few data in the literature on changes in inflammatory markers when lidocaine is administered perioperatively in patients with colorectal cancer. In patients undergoing surgery for colon cancer, the aim is to conduct a double-blind placebo-controlled study to determine differences in levels of pro-inflammatory markers, postoperative pain and opioid analgesic consumption in the first two days after surgery, and the time to first postoperative bowel movement. Groups of patients receiving perioperative lidocaine infusion, high dose dexamethasone or placebo will be compared.Read full original descriptionShow less
Effect of Perioperative Intravenous Infusion of Lidocaine on the Postoperative Course and the Immune Response in Patients Undergoing Surgery for Colon Cancer - the PILDI Study
There are very few data in the literature on changes in inflammatory markers when lidocaine is administered perioperatively in patients with colorectal cancer. In patients undergoing surgery for colon cancer, the aim is to conduct a double-blind placebo-controlled study to determine differences in levels of pro-inflammatory markers, postoperative pain and opioid analgesic consumption in the first two days after surgery, and the time to first postoperative bowel movement. Groups of patients receiving perioperative lidocaine infusion, high dose dexamethasone or placebo will be compared.
Inclusion: colon cancer of any stage of the disease for which elective laparoscopic colon resection and colonic anastomosis will be performed,; age of patients between 18 and 80 years,; low to moderate risk of anesthesia (ASA up to and including 3),; ability to understand the study and to sign an informed consent to participate in the study.
Exclusion: patients receiving neoadjuvant chemotherapy,; chronic corticosteroid therapy; known allergy to lidocaine; cardiac rhythm disturbances (bradycardia < 45 beats/min, complete heart block, use of group III antiarrhythmics),; status post cardiac arrest,; severe hepatic impairment (cirrhosis, ascites, bleeding disorders, jaundice, encephalopathy),; epilepsy,; active infection,; presence of viral or systemic fungal disease,; ulcerative gastric or duodenal disease,; renal disease (hamodialysis, creatinine clearance <30 mL/min),; pregnancy or breastfeeding,; porphyria,; myasthenia gravis,; uncontrolled psychotic state,.