Tests thrombectomy plus medicine for a large back-of-brain stroke
Studies clot removal with standard medicine in adults with a blocked brain artery.
Plain-language title generated from the registry record
Registry title: Efficacy and Safety of Endovascular Thrombectomy in Acute Ischemic Stroke With Posterior Circulation Large Infarct
Key facts
- Where
- Beijing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06924996, who can take part
Where in China
- Beijing Tiantan HospitalBeijing, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Feng Gao
- Trial code
- NCT06924996
- Record updated
- 13 April 2025
- Original description
The purpose of this study is to evaluate whether endovascular thrombectomy (EVT) combined with best medical management (BMM) leads to better functional outcomes than BMM alone in patients with acute basilar artery occlusion with posterior circulation large infarct.Read full original descriptionShow less
Efficacy and Safety of Endovascular Thrombectomy in Acute Ischemic Stroke With Posterior Circulation Large Infarct: A Multicenter, Prospective, Cohort Study
The purpose of this study is to evaluate whether endovascular thrombectomy (EVT) combined with best medical management (BMM) leads to better functional outcomes than BMM alone in patients with acute basilar artery occlusion with posterior circulation large infarct.
Inclusion: Age 18-80 years old; Acute ischemic stroke in the posterior circulation, the onset of stroke (or last well known) to the enrollment time within 24 hours; CTA/MRA/DSA confirmed acute basilar artery occlusion; Posterior circulation large infarct: NCCT or DWI showed pc-ASPECTS ≤ 5 points, or pontine midbrain index (PMI) ≥ 3 points; NIHSS score ≥10 points after the onset of the stroke and before enrollment; Able to live independently before the onset of the disease (mRS score ≤2 points); The subject or legal representative is able to sign the informed consent form.
Exclusion: Acute cerebral infarction within 48 hours after cardiovascular and cerebrovascular intervention or major surgery (patients more than 48 hours can be enrolled); Intracranial hemorrhage (except microhemorrhage) on CT/MRI ; Known severe allergy to contrast agents (except for mild rash); Refractory hypertension (defined as systolic blood pressure > 185 mmHg or diastolic blood pressure >110 mmHg) that cannot be controlled by drug therapy; CT/MRI revealed large infarction in the cerebellar hemisphere, with significant mass effect causing compression of the fourth ventricle or brainstem; CT or MRI showed bilateral complete thalamic infarction; Occlusion of anterior and posterior circulation arteries confirmed by CTA/MRA/DSA; The presence of intracranial tumors (except for small meningiomas and cerebral aneurysms with a diameter of <3mm); Patients with known or highly suspected chronic basilar artery occlusion; Known pregnant or lactating females, or positive pregnancy test before enrollment.