Tests two ablation approaches for persistent atrial fibrillation heart rhythm
Compares pulmonary vein isolation alone with added posterior wall isolation in persistent atrial fibrillation.
Plain-language title generated from the registry record
Registry title: PVI Alone vs PVI With Posterior Wall Isolation for Pulse-Field Ablation in Persistent AF
Key facts
- Where
- Seoul, South KoreaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 80 years old?
Source: NCT06929897, who can take part
Where in South Korea
- Ewha Womans University Mokdong HospitoalSeoul, South KoreaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Ewha Womans University Mokdong Hospital
- Trial code
- NCT06929897
- Record updated
- 16 July 2026
- Original description
To date, no optimal treatment has been established to improve outcomes in patients with persistent atrial fibrillation. The safety and efficacy of pulsed-field ablation (PFA) have been demonstrated in several studies, and its clinical application is expanding.Read full original descriptionShow less
Comparison of Pulmonary Vein Isolation Alone Versus Pulmonary Vein Isolation With Posterior Wall Isolation for Pulse-Field Ablation in Persistent Atrial Fibrillation: A Prospective Randomized Controlled Trial
To date, no optimal treatment has been established to improve outcomes in patients with persistent atrial fibrillation. The safety and efficacy of pulsed-field ablation (PFA) have been demonstrated in several studies, and its clinical application is expanding.
- In patients with persistent atrial fibrillation, can the addition of posterior wall isolation (PWI) following pulmonary vein isolation (PVI) using PFA reduce recurrence?
Participants will:
* Undergo either PVI alone or PVI with additional left atrial posterior wall isolation (PWI) * Visit the clinic to assess for recurrence of atrial tachyarrhythmias
Inclusion: Patients aged 20 to 80 years who are candidates for catheter ablation for persistent atrial fibrillation; Patients eligible for catheter ablation according to existing clinical guidelines; Those without clinically significant structural heart disease (e.g., severe mitral regurgitation); Those without contraindications to anticoagulation therapy.
Exclusion: History of prior cardiac surgery (e.g., Maze procedure, coronary artery bypass grafting); Patients with contraindications to anticoagulation therapy and antiarrhythmic drugs; Valvular atrial fibrillation (e.g., mitral stenosis > grade 2, mechanical valve, prior mitral valve repair); Patients with drug or alcohol addiction; Atrial fibrillation associated with severe congenital heart disease or structural heart disease; History of atrial fibrillation catheter ablation within the past 12 months; Patients with active internal bleeding; Patients with severe comorbid conditions; Any other conditions deemed by the investigator to make the patient unsuitable for study participation; Patients with severe left ventricular dysfunction (left ventricular ejection fraction <30%); Patients with contraindications to general anesthesia or sedation for the procedure; Patients with an expected survival of less than one year; Pregnant or breastfeeding women.