Comparing two medicines to calm heart response during breathing-tube placement in hypertensive patients
Compares oral melatonin and inhaled dexmedetomidine before anesthesia in hypertensive adults aged 40 to 60.
Key facts
- Who runs it
- Tanta University
- Where
- Tanta, EgyptSee the site
- Trial code
- Registry title
- Oral Melatonin VS Nebulized Dexmedetomidine Premedication on Attenuation of Hemodynamic Response to Direct Laryngoscopy and Tracheal Intubation in Hypertensive Patients
- Status
- Not yet recruiting
- Phase
- Phase 2/3
- People taking part
- 70 people, planned
- Started
- Apr 2025
- Planned end
- Apr 2026
- Type of study
- Interventional, 2 groups
- Treatments tested
- Dexmedetomidine
- Melatonin
- Record updated
- 20 April 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 40-60 with controlled high blood pressure who are planned for elective surgery under general anesthesia.
- Age
- 40 to 60 years
- Sex
- Men and women can join.
- Disease stage
- Controlled high blood pressure (hypertension), ASA physical status II, planned for elective surgery under general anesthesia.
- Earlier treatment
- People taking beta blockers, oral hypoglycemics, anti-depressants, anti-convulsants, anti-psychotics or thyroid medications cannot join.
Main reasons for not taking part
- Expected difficult intubation
- Body Mass Index (BMI) > 30 kg/m2
- Heart rate < 50 or heart block
- End stage kidney or liver disease
- Pregnant or breastfeeding women
The registry criteria, word for word
Show all 12 criteriaShow less
Who can take part
- Age (40-60) years of both genders
- Controlled hypertensive patients
- Categorized as ASA physical status II
- Planning to do an elective surgery under General Anesthesia
Who cannot take part
- Patients on beta blocker, oral hypoglycemics, anti-depressants, anti-convulsants, anti- psychotics and thyroid medications
- History of allergy to the drugs of the study
- Patients with Heart rate<50 or Heart block
- End stage renal and hepatic disease
- Patient refusal to participate in the study
- Patient with expected difficult intubation
- Body Mass Index (BMI) > 30 kg/m2
- Pregnant or lactating females
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 60 years old?
Where in Egypt
- Tanta University HospitalTanta, EgyptContact: Aya GAE Ismaeil, MBBCHNo longer taking part
About the trial
What the trial wants to find out
The aim of this study is to compare the efficacy of oral melatonin versus nebulized dexmedetomidine in attenuating the hemodynamic response to direct laryngoscopy and endotracheal intubation in controlled hypertensive patients prepared for general anesthesia
The 2 groups in the trial
- Dexmedetomidine groupTreatment being tested
Participants in this group will receive nebulized dexmedetomidine (1μg/kg) one hour before induction of anesthesia
Treatment: Dexmedetomidine
- Melatonin groupTreatment being tested
Participants in this group will receive melatonin oral tablet (5mg) one hour before induction of anesthesia
Treatment: Melatonin
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Comparative Study Between Oral Melatonin and Nebulized Dexmedetomidine Premedication on Attenuation of Hemodynamic Response to Direct Laryngoscopy and Tracheal Intubation in Hypertensive Patients: A Prospective Randomized Trial
- Plain-language title
- Comparing two medicines to calm heart response during breathing-tube placement in hypertensive patientsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT06935292, who can take part
- Record updated
- 20 April 2025