Exercise Training to Support Quality of Life During Chemotherapy for Colorectal Cancer
Tests structured exercise in adults with metastatic colorectal cancer starting first-line chemotherapy.
Plain-language title generated from the registry record
Registry title: Randomized Controlled Trial of the Effects of Combined Resistance and AerobiC Exercise on Health-related Quality of Life in Patients Undergoing First-line Chemotherapy for Metastatic Colorectal Cancer (REACH)
Key facts
- Where
- Copenhagen, Herlev, Hillerød, and Roskilde, DenmarkSee the 4 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who are about to start first-line chemotherapy for colorectal cancer that has spread. It compares 18 weeks of structured exercise training with no exercise programme.
- Age
- 18 years or older
- Sex
- Men and women can join
- Disease stage
- Metastatic colorectal cancer, scheduled for first-line chemotherapy
- Earlier treatment
- Must be scheduled to start first-line chemotherapy. Must not have done regular structured moderate-to-high aerobic exercise for more than 30 minutes, more than once a week, in the past 3 months.
Main reasons for not taking part
- Pregnancy
- Life expectancy under 6 months
- Medical reasons that make maximal exercise unsafe, as set by the Danish Society of Cardiology
- ECOG performance status above 2
- Cannot understand Danish or English
Read by machine on 9 November 2026.
Where in Denmark
- Centre for Physical Activity Research, Copenhagen Univerisity Hospital - RigshospitaletCopenhagen, DenmarkTaking people
- Herlev and Gentofte HospitalHerlev, DenmarkTaking people
- North Zealand University Hospital, HillerødHillerød, DenmarkTaking people
- Zealand University Hospital, RoskildeRoskilde, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Copenhagen University Hospital, Rigshospitalet
- Trial code
- NCT06938971
- Record updated
- 13 May 2026
- Original description
The primary objective of this trial is to compare the effects of 18 weeks structured exercise training versus on control on healt-related quality of life in patients with mCRC undergoing first-line chemotherapy.Read full original descriptionShow less
Effects of Exercise Training on Health-related Quality of Life in Patients With Unresectable Metastatic Colorectal Cancer: A Multi-center Randomized Controlled Trial
The primary objective of this trial is to compare the effects of 18 weeks structured exercise training versus on control on healt-related quality of life in patients with mCRC undergoing first-line chemotherapy.
Inclusion: Adults (≥18 years of age) schduled to undergo first-line chemotherapy for the treatment of metastatic colorectal cancer.
Exclusion: Pregnancy; A life expectancy of < 6 months; Absolute contraindications to maximal exercise, as per the recommendations by the Danish Society of Cardiology; ECOG (Eastern Cooperative Oncology Group) performance status > 2; Inability to understand the Danish or English language; Engagement in structured moderate-to-high aerobic exercise training for >30 min >1 times/week for the past 3 months at the time of inclusion.