Exercise Training to Support Quality of Life During Chemotherapy for Colorectal Cancer
Tests structured exercise in adults with metastatic colorectal cancer starting first-line chemotherapy.
Plain-language title generated from the registry record
Registry title: Randomized Controlled Trial of the Effects of Combined Resistance and AerobiC Exercise on Health-related Quality of Life in Patients Undergoing First-line Chemotherapy for Metastatic Colorectal Cancer (REACH)
Key facts
- Where
- Copenhagen, Herlev, Hillerød, and Roskilde, DenmarkSee the 4 sites
Where in Denmark
- Centre for Physical Activity Research, Copenhagen Univerisity Hospital - RigshospitaletCopenhagen, DenmarkTaking people
- Herlev and Gentofte HospitalHerlev, DenmarkTaking people
- North Zealand University Hospital, HillerødHillerød, DenmarkTaking people
- Zealand University Hospital, RoskildeRoskilde, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Copenhagen University Hospital, Rigshospitalet
- Trial code
- NCT06938971
- Record updated
- 13 May 2026
- Original description
The primary objective of this trial is to compare the effects of 18 weeks structured exercise training versus on control on healt-related quality of life in patients with mCRC undergoing first-line chemotherapy.Read full original descriptionShow less
Effects of Exercise Training on Health-related Quality of Life in Patients With Unresectable Metastatic Colorectal Cancer: A Multi-center Randomized Controlled Trial
The primary objective of this trial is to compare the effects of 18 weeks structured exercise training versus on control on healt-related quality of life in patients with mCRC undergoing first-line chemotherapy.
Inclusion: Adults (≥18 years of age) schduled to undergo first-line chemotherapy for the treatment of metastatic colorectal cancer.
Exclusion: Pregnancy; A life expectancy of < 6 months; Absolute contraindications to maximal exercise, as per the recommendations by the Danish Society of Cardiology; ECOG (Eastern Cooperative Oncology Group) performance status > 2; Inability to understand the Danish or English language; Engagement in structured moderate-to-high aerobic exercise training for >30 min >1 times/week for the past 3 months at the time of inclusion.