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Taking people in United StatesNo phase

Follows pregnant women with chronic neurological conditions and their infants' health

Collects pregnancy information and samples from women with multiple sclerosis or related conditions.

Plain-language title generated from the registry record
Registry title: Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA)

Key facts

Where
San Francisco, United StatesSee the site

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 64 years old?

Source: NCT06940323, who can take part

Where in United States

  • University of California San FranciscoSan Francisco, United StatesTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
Print a page for my doctor

Trial details

Who runs it
University of California, San Francisco
Trial code
NCT06940323
Record updated
11 August 2026
Original description
PRISMA, is a pregnancy registry study, focused on comprehensively collecting information about pregnancy in women with chronic neurological conditions from across the United States and internationally.Read full original descriptionShow less

Pregnancy Registry, Infants, Serum/Milk Analysis (PRISMA): Pregnancy Registry for Women With Chronic Conditions

PRISMA, is a pregnancy registry study, focused on comprehensively collecting information about pregnancy in women with chronic neurological conditions from across the United States and internationally.

Depending on their specific condition (MS, CIS, NMOSD, or other) and their specific treatment, participants will be asked to contribute to different aspects of the study. (1) The biosamples will be blood, breast milk, infant stool, maternal stool and vaginal swab samples, collected at specific time points. (2) The online surveys will be collected at specific time points. All study activities will be discussed with participants upon enrollment.

By collecting this information, the investigators hope to gain deeper insights into the relationship between pregnancy, the neurological condition, and maternal and infant health. For example, one of the sub-studies focuses on breast milk collection for women planning postpartum treatment with Ocrevus, Rituxan, Briumvi or Kesimpta.

This study is fully remote and all sample collection is optional, so participants can choose which types of samples they wish to provide. For blood draws, participants can schedule a home visit through ExamOne, making participation even more convenient.

The investigators aim to enroll women with chronic neurological conditions who are planning pregnancy, currently pregnant, or within one year postpartum.

Inclusion: Pregnant or contemplating pregnancy; Female, aged 18 to 64 years; Diagnosis of one of the following conditions:; Clinically Isolated Syndrome (CIS) or Multiple Sclerosis (MS), based on the 2010 McDonald Criteria; Neuromyelitis Optica Spectrum Disorder (NMOSD); Inflammatory Bowel Disease (IBD); Rheumatoid Arthritis (RA); Myasthenia Gravis; Lupus; Other chronic neurological conditions; Willing to provide biosamples and/or complete surveys at specified timepoints; Women without a chronic condition who are pregnant or contemplating pregnancy (as part of the control group).

Exclusion: Unwillingness to provide informed consent.

ClinicalTrials.gov NCT06940323