Tests magnetic brain stimulation after clot removal in acute stroke
Tests magnetic brain stimulation alongside clot removal in adults with stroke.
Key facts
- Who runs it
- Yi Yang
- Where
- Changchun, ChinaSee the site
- Trial code
- Registry title
- iTBS for Acute Ischemic Stroke After Thrombectomy
- Status
- Recruiting
- People taking part
- 178 people, planned
- Started
- 25 Apr 2025
- Planned end
- 1 Aug 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- intermittent theta burst stimulation
- sham intermittent theta burst stimulation
- Record updated
- 30 April 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a stroke caused by a blocked large artery at the front of the brain. They must have had a successful clot-removal procedure (thrombectomy). The trial tests a brain stimulation treatment (iTBS).
- Age
- 18 to 85 years
- Sex
- All sexes can join.
- Disease stage
- Acute ischemic stroke from a blocked large artery in the front of the brain (internal carotid artery, M1 or M2 segment of the middle cerebral artery), confirmed by CTA or DSA. Thrombectomy within 24 hours of symptom onset. NIHSS score 5-25 at 24 hours after thrombectomy, with at least 2 points in at least one limb.
- Earlier treatment
- Must have had mechanical thrombectomy within 24 hours of symptom onset, with good blood flow restored afterwards (eTICI score ≥ 2b).
Main reasons for not taking part
- Disability before the stroke (mRS score ≥2)
- PH2-type bleeding in the brain on CT after thrombectomy
- Intracranial stent placed during thrombectomy
- Epilepsy or seizures in the past, pacemaker, cochlear implant or other electronic or magnetic-sensitive device
- Expected survival under 3 months, or taking part in another interventional study
The registry criteria, word for word
Show all 13 criteriaShow less
Who can take part
- 1) Age 18-85 years, regardless of gender
- 2) Acute ischemic stroke caused by occlusion of the anterior circulation large vessels (internal carotid artery, M1 or M2 segment of the middle cerebral artery), verified by CTA or DSA
- 3) Mechanical thrombectomy (MT) performed within 24 hours of symptom onset
- 4) Successful Reperfusion: Post-MT eTICI score ≥ 2b
- 5) NIHSS score 5-25 at 24 hours post-MT, with ≥2 points in at least one limb
Who cannot take part
- 1) Pre-stroke modified Rankin Scale (mRS) score ≥2
- 2) PH2-type intracranial hemorrhage on brain CT post-MT
- 4) Contraindications to iTBS: History of epilepsy or seizures, implanted cardiac pacemakers, cochlear implants, or other electronic/magnetic-sensitive devices
- 5) Severe consciousness impairment, cognitive dysfunction, or psychiatric disorders preventing compliance with iTBS
- 6) Expected survival <3 months due to other medical conditions or inability to complete follow-up for any reason
- 8) Any other condition deemed unsuitable for enrollment by the investigator
- 3) Patients who underwent intracranial stent placement during MT
- 7) Participation in another interventional study
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Where in China
- The First Hospital of Jilin UniversityChangchun, ChinaContact: Yi Yang, MD, PhDTaking people
About the trial
What the trial wants to find out
The goal of this randomized, single-blind, parallel-controlled clinical trial is to evaluate the efficacy and safety of intermittent theta burst stimulation (iTBS) as an adjunctive therapy for acute anterior circulation ischemic stroke patients who have undergone successful mechanical thrombectomy (MT). The study population includes adults aged 18-85 with NIHSS scores 5-25 post-MT and eTICI≥2b reperfusion.
The 2 groups in the trial
- iTBSExisting treatment, for comparison
Patients are treated with intermittent theta burst stimulation (iTBS).
Treatment: intermittent theta burst stimulation
- sham-iTBSSham treatment, for comparison
Patients are treated with sham intermittent theta burst stimulation (sham-iTBS).
Treatment: sham intermittent theta burst stimulation
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Efficacy and Safety of Intermittent Theta Burst Stimulation in Acute Anterior Circulation Ischemic Stroke Patients Undergoing Mechanical Thrombectomy
- Plain-language title
- Tests magnetic brain stimulation after clot removal in acute strokeGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT06941961, who can take part
- Record updated
- 30 April 2025