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Water Exercise Compared With Land Exercise for Knee Arthritis in Men With Obesity

Compares water-based exercise with land-based exercise in men with obesity and knee osteoarthritis.

Plain-language title generated from the registry record
Registry title: WATERinMOTION Aquatic Therapy in Obese Men With Knee Osteoarthritis

Key facts

Where
Zahedan, IranSee the site

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for men aged 45-65 who are obese and have knee osteoarthritis. It compares aquatic therapy with land-based exercise.

Age
45 to 65 years
Sex
Men only
Disease stage
Knee osteoarthritis seen on X-ray (Kellgren-Lawrence grade 2-3), with a WOMAC pain score of 25/50 or higher. BMI of 30 kg/m² or higher.
Earlier treatment
No injection into the knee joint within the last 3 months.

Main reasons for not taking part

  • Inflammatory arthritis (for example, rheumatoid arthritis)
  • Injection into the joint within the last 3 months
  • Medical reasons that make aquatic exercise unsafe

Read by machine on 12 November 2026.

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 45 and 65 years old?

Source: NCT06946329, who can take part

Where in Iran

  • Sport Sciences DepartmentZahedan, IranNo longer taking part

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it
University of Sistan and Baluchestan
Trial code
NCT06946329
Record updated
27 April 2025
Original description
This RCT evaluates whether WATERinMOTION aquatic therapy improves pain, function, and quality of life more effectively than land-based exercise in obese men with knee osteoarthritis (OA). We will assess clinical outcomes (WOMAC), serum biomarkers (COMP, IL-6), and real-world activity (accelerometry) at baseline, 8 weeks, and 6 months.Read full original descriptionShow less

Mechanistic and Functional Outcomes of WATERinMOTION Aquatic Therapy in Obese Men With Knee Osteoarthritis: A Randomized Controlled Trial With 6-Month Follow-Up

This RCT evaluates whether WATERinMOTION aquatic therapy improves pain, function, and quality of life more effectively than land-based exercise in obese men with knee osteoarthritis (OA). We will assess clinical outcomes (WOMAC), serum biomarkers (COMP, IL-6), and real-world activity (accelerometry) at baseline, 8 weeks, and 6 months.

Inclusion: Males aged 45-65; BMI ≥30 kg/m²; Radiographic knee OA (Kellgren-Lawrence grade 2-3); WOMAC pain score ≥25/50.

Exclusion: Inflammatory arthritis (e.g., rheumatoid); Intra-articular injections within 3 months; Contraindications to aquatic exercise.

ClinicalTrials.gov NCT06946329