Text Reminders and Rewards to Support Long-Term HIV Medication Use
Tests daily text reminders and rewards for timely HIV medicine intake in adults.
Plain-language title generated from the registry record
Registry title: INcentives and ReMINDers to Improve Long-term Medication Adherence (INMIND)
Key facts
- Where
- Kampala, UgandaSee the site
Where in Uganda
- Mildmay UgandaKampala, UgandaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- RAND
- Trial code
- NCT06949774
- Record updated
- 14 July 2026
- Original description
Low medication adherence when initiating antiretroviral treatment (ART) is a key barrier to HIV virologic suppression, resulting in avoidable cases of drug resistance, death, and viral transmission. Routinized pill-taking can lead to successful long-term ART adherence, and short-term behavioral economics-based supports are a novel way to overcome the limited success of existing routinization interventions. This study proposes to test this combined approach for promoting long-term ART adherence using a Stage III Sequential, Multiple Assignment, Randomized Trial (SMART) design in one of the largest HIV clinics in Uganda to identify the most cost-effective adaptive intervention that if found effective is generalizable to other settings and other chronic diseases.Read full original descriptionShow less
INcentives and ReMINDers to Improve Long-term Medication Adherence
Low medication adherence when initiating antiretroviral treatment (ART) is a key barrier to HIV virologic suppression, resulting in avoidable cases of drug resistance, death, and viral transmission. Routinized pill-taking can lead to successful long-term ART adherence, and short-term behavioral economics-based supports are a novel way to overcome the limited success of existing routinization interventions. This study proposes to test this combined approach for promoting long-term ART adherence using a Stage III Sequential, Multiple Assignment, Randomized Trial (SMART) design in one of the largest HIV clinics in Uganda to identify the most cost-effective adaptive intervention that if found effective is generalizable to other settings and other chronic diseases.
Inclusion: Male and female clients age 18 and older; Started ART at Mildmay or another clinic within the preceding 2 months; Able to speak and understand either English or Luganda; Have their own cell phone or have consistent access to someone else's phone; Willing to receive daily text messages for the 6 months of intervention duration; Willing and able to use the WisePill device distributed for adherence verification for the duration of the study.
Exclusion: Not mentally fit to consent; Language other than Luganda or English; Not willing to consistently use the Wisepill device for adherence measurement.