Text Reminders and Rewards to Support Long-Term HIV Medication Use
Tests daily text reminders and rewards for timely HIV medicine intake in adults.
Plain-language title generated from the registry record
Registry title: INcentives and ReMINDers to Improve Long-term Medication Adherence (INMIND)
Key facts
- Where
- Kampala, UgandaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who started HIV treatment (ART) in the last 2 months and can get daily text messages.
- Age
- 18 years and older
- Sex
- Men and women
- Earlier treatment
- Started ART at Mildmay or another clinic within the last 2 months.
Main reasons for not taking part
- Not mentally fit to consent
- Speaks a language other than Luganda or English
- Not willing to use the Wisepill device all the time
Read by machine on 12 November 2026.
Where in Uganda
- Mildmay UgandaKampala, UgandaContact: Lillian LukuseTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- RAND
- Trial code
- NCT06949774
- Record updated
- 14 July 2026
- Original description
Low medication adherence when initiating antiretroviral treatment (ART) is a key barrier to HIV virologic suppression, resulting in avoidable cases of drug resistance, death, and viral transmission. Routinized pill-taking can lead to successful long-term ART adherence, and short-term behavioral economics-based supports are a novel way to overcome the limited success of existing routinization interventions. This study proposes to test this combined approach for promoting long-term ART adherence using a Stage III Sequential, Multiple Assignment, Randomized Trial (SMART) design in one of the largest HIV clinics in Uganda to identify the most cost-effective adaptive intervention that if found effective is generalizable to other settings and other chronic diseases.Read full original descriptionShow less
INcentives and ReMINDers to Improve Long-term Medication Adherence
Low medication adherence when initiating antiretroviral treatment (ART) is a key barrier to HIV virologic suppression, resulting in avoidable cases of drug resistance, death, and viral transmission. Routinized pill-taking can lead to successful long-term ART adherence, and short-term behavioral economics-based supports are a novel way to overcome the limited success of existing routinization interventions. This study proposes to test this combined approach for promoting long-term ART adherence using a Stage III Sequential, Multiple Assignment, Randomized Trial (SMART) design in one of the largest HIV clinics in Uganda to identify the most cost-effective adaptive intervention that if found effective is generalizable to other settings and other chronic diseases.
Inclusion: Male and female clients age 18 and older; Started ART at Mildmay or another clinic within the preceding 2 months; Able to speak and understand either English or Luganda; Have their own cell phone or have consistent access to someone else's phone; Willing to receive daily text messages for the 6 months of intervention duration; Willing and able to use the WisePill device distributed for adherence verification for the duration of the study.
Exclusion: Not mentally fit to consent; Language other than Luganda or English; Not willing to consistently use the Wisepill device for adherence measurement.