Eye surgery comparison for angle-closure glaucoma patients
Compares two eye surgeries for pressure in people with angle-closure glaucoma.
Plain-language title generated from the registry record
Registry title: Comparison of Phaco Surgery With Goniosynechialysis Versus Trabeculectomy in Glaucoma Treatment
Key facts
- Where
- Ho Chi Minh City, VietnamSee the site
Where in Vietnam
- HCMC University of Medicine and PharmacyHo Chi Minh City, VietnamTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Medicine and Pharmacy at Ho Chi Minh City
- Trial code
- NCT06952153
- Record updated
- 11 September 2025
- Original description
The goal of this clinical trial is to learn whether phacoemulsification combined with goniosynechialysis (Phaco-GSL) is as effective and safe as trabeculectomy in treating patients with primary angle-closure glaucoma.Read full original descriptionShow less
Comparison of Phaco Surgery and Goniosynechialysis Versus Trabeculectomy Outcomes in Glaucoma Patients
The goal of this clinical trial is to learn whether phacoemulsification combined with goniosynechialysis (Phaco-GSL) is as effective and safe as trabeculectomy in treating patients with primary angle-closure glaucoma.
The main questions it aims to answer are:
* Does Phaco-GSL provide similar or better intraocular pressure (IOP) control compared to trabeculectomy? * What are the rates of postoperative complications or adverse events between the two surgical approaches? * How do the two procedures compare in terms of visual acuity recovery and need for glaucoma medications?
Researchers will compare Phaco-GSL to trabeculectomy to determine which procedure offers better overall outcomes for patients with angle-closure glaucoma.
Participants will:
Be randomly assigned to undergo either Phaco-GSL or trabeculectomy Attend scheduled follow-up visits at regular intervals (e.g., 1 week, 1 month, 3 months, 6 months, 12 months) for eye exams and pressure checks
Inclusion: Age ≥ 40 years; Peripheral anterior synechiae (PAS) >180°; Glaucomatous optic neuropathy with visual field loss; Intraocular pressure (IOP) > 21 mmHg despite medication; Ability to consent and comply with follow-up; Cataract grade 1 to 3 according to LOCS III; Best corrected visual acuity (BCVA) ≥ 0.3 logMAR (equivalent to 20/40 Snellen or worse).
Exclusion: Prior ocular surgeries or laser peripheral iridotomy (PI); Chronic corticosteroid use; Allergy to 5-fluorouracil (5-FU), if used postoperatively; Irreversible corneal disease; Very advanced glaucoma (only light perception vision); Secondary angle-closure etiologies; Poor follow-up compliance; Cataract grade 4 or 5 (LOCS III); Phacomorphic, phacolytic, or subluxated cataracts.