Taking peopleNo phase

Using MRI stiffness scans to assess meningioma tumors before surgery

Tests a special MRI scan of tumor stiffness in adults having meningioma surgery.

Key facts

Who runs it: Shengjing Hospital
Where: China1 site in 1 countryChoose a country to see its sites
Trial code: NCT06955208
Registry title: 3D MRE-Based Evaluation of Meningioma Mechanical Properties and Histological Features
Status: Recruiting
People taking part: 300 people, planned
Started: 19 Oct 2022
Expected to end: 9 Oct 2027
Type of study: Interventional
Treatments tested: Magnetic Resonance Elastography
Intraoperative Assessment and Recording
Record updated: 12 February 2026

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with a meningioma (a tumour of the brain's covering layers) who are going to have surgery to remove it. Before surgery they get a special MRI scan that measures how stiff the tumour is.

Age: 18 Years to 80 Years
Sex: All
Disease stage: Meningioma that will be removed by surgery.

Main reasons for not taking part

Metal implants or objects in the body, such as pacemakers, metal heart valves, metal joints, dentures that cannot be removed, insulin pumps or contraceptive rings
Pregnant women in the first trimester (within three months)
Severe fear of closed spaces or severe anxiety, or not able to tolerate the MRE scan
Severe fever
Blood vessel malformations or aneurysms (bulging blood vessels)

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

All patients undergoing meningeoma resection surgery are eligible for inclusion in the study cohort

Who cannot take part

Patients with metallic implants or foreign bodies in their bodies (pacemakers, artificial metallic heart valves, metal joints, metal implants, and those who can not remove dentures, insulin pumps, or contraceptive rings)
Pregnant women in the first trimester (within three months)
Patients with severe claustrophobia or anxiety
Patients with severe fever
Patients who can not tolerate MRE
Patients with vascular malformations and aneurysms
Patients who do not sign an informed consent

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 80 years old?

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

This prospective single-center study aims to evaluate the feasibility and clinical utility of three-dimensional magnetic resonance elastography (3D MRE) in assessing tumor stiffness and adhesion in patients with meningioma undergoing surgical resection. By correlating preoperative MRE-derived stiffness and adhesion maps with intraoperative findings and histopathological features, the study seeks to determine whether MRE can serve as a noninvasive imaging biomarker for surgical planning, risk stratification, and prediction of tumor behavior.

The group in the trial

MRE-Guided Surgery GroupTreatment being tested
Participants in this group will undergo preoperative three-dimensional magnetic resonance elastography (3D MRE) in addition to routine MRI. MRE will be used to quantify tumor stiffness and generate a three-dimensional adhesion map. These imaging findings will be provided to the neurosurgical team prior to surgery to assist in planning the surgical approach and anticipating tumor consistency and adhesiveness. Intraoperative outcomes such as resection time, blood loss, and dissection difficulty will be recorded and analyzed in relation to preoperative MRE parameters.
Treatment: Magnetic Resonance Elastography and Intraoperative Assessment and Recording