Tests alcohol sclerotherapy for ovarian endometrioma and pelvic pain
Tests a procedure for ovarian cysts from endometriosis in women aged 18 to 45.
Plain-language title generated from the registry record
Registry title: Effect of Alcohol Sclerotherapy on Pelvic Pain and Quality of Life in Women With Ovarian Endometriosis
Key facts
- Where
- Badalona, Barcelona, Cieza, Granada, Igualada, Jaén, L'hospitalet De Llobregat, L'Hospitalet de Llobregat, Lleida, Logroño, Madrid, Martorell, Palma de Mallorca, Reus, Sabadell, San Cristóbal de La Laguna, San Javier, Sant Boi de Llobregat, Tarragona, Valencia, Valladolid, Viladecans, Vitoria-Gasteiz, and Zaragoza, SpainSee the 26 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 45 years old?
Source: NCT06955221, who can take part
Where in Spain
- Hospital Universitario Germans Trias i PujolBadalona, SpainNot yet recruiting
- Hospital del MarBarcelona, SpainTaking people
- Hospital de la Vega Lorenzo GuiraoCieza, SpainNot yet recruiting
- Clínica SanabriaGranada, SpainNot yet recruiting
- Consorci Sanitari de l'AnoiaIgualada, SpainTaking people
- Hospital Universitario de JaénJaén, SpainNot yet recruiting
- Consorci Sanitari IntegralL'hospitalet De Llobregat, SpainTaking people
- Hospital Universitario de BellvitgeL'Hospitalet de Llobregat, SpainTaking people
- Hospital Universitario Arnau de VilanovaLleida, SpainNot yet recruiting
- Hospital Universitario San PedroLogroño, SpainNot yet recruiting
- Hospital Clínico San CarlosMadrid, SpainTaking people
- Hospital Universitario 12 de OctubreMadrid, SpainTaking people
- Hospital Universitario Ramón y CajalMadrid, SpainTaking people
- Hospital San Juan de Dios de MartorellMartorell, SpainNot yet recruiting
- Hospital Universitario Son EspasesPalma de Mallorca, SpainNot yet recruiting
- Hospital Universitari Sant Joan de ReusReus, SpainNot yet recruiting
- Consorci Corporació Sanitària Parc TaulíSabadell, SpainNot yet recruiting
- Hospital Universitario de CanariasSan Cristóbal de La Laguna, SpainNot yet recruiting
- Hospital General Universitario Los Arcos del Mar MenorSan Javier, SpainTaking people
- Parc Sanitari Sant Joan de DéuSant Boi de Llobregat, SpainNot yet recruiting
- Hospital Universitario Joan XXIIITarragona, SpainNot yet recruiting
- Consorcio Hospital General Universitario de ValenciaValencia, SpainNot yet recruiting
- Hospital Recoletas Salud Campo GrandeValladolid, SpainTaking people
- Hospital de ViladecansViladecans, SpainTaking people
- Hospital Universitario de Álava - TxagorritxuVitoria-Gasteiz, SpainNot yet recruiting
- Hospital Clinico Universitario Lozano BlesaZaragoza, SpainNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Hospital Universitari de Bellvitge
- Trial code
- NCT06955221
- Record updated
- 10 November 2026
- Original description
The goal of this clinical trial is to evaluate whether ultrasound-guided alcohol sclerotherapy can improve pelvic pain and quality of life in women aged 18 to 45 diagnosed with ovarian endometriomas, compared to expectant management.Read full original descriptionShow less
Effect of US-guided Alcohol Sclerotherapy for Endometriomas on Pelvic Pain and Quality of Life
The goal of this clinical trial is to evaluate whether ultrasound-guided alcohol sclerotherapy can improve pelvic pain and quality of life in women aged 18 to 45 diagnosed with ovarian endometriomas, compared to expectant management.
The main questions it aims to answer are:
1. - Does sclerotherapy significantly reduce pelvic pain compared to expectant management? 2. - Does sclerotherapy improve quality of life as measured by the EHP-5 score?
Researchers will compare the sclerotherapy group to the expectant management group to determine whether the intervention leads to greater improvement in pain and quality of life.
Participants will:
* Be randomly assigned to one of two groups: (1) Sclerotherapy group: undergo ultrasound-guided puncture and alcohol sclerotherapy; (2) Control group: expectant management * Complete quality of life and pain assessments at baseline and after 6 months * Provide blood and urine samples for biomarker analysis (e.g., cortisol, IL-6, hsCRP, catecholamines) * Undergo ovarian reserve assessments (AMH, antral follicle count) * Be followed for adverse events, recurrence, fertility outcomes, and treatment-related costs
The study will follow an intention-to-treat and per-protocol analysis approach.
Inclusion: Female sex; Age ≥18 and ≤45 years; Ultrasound suspicion of unilocular endometrioma or with a thin septum less than 3 mm; Size between 30-100 mm, persistent for at least 3-6 months since diagnosis; Ca125 marker <300 UI/mL and HE4 < 70 pM; Signed informed consent.
Exclusion: Indication for surgical treatment of the endometrioma due to suspected severe extra-ovarian endometriosis or any other cause; History of ovarian or uterine cancer; Ultrasound suspicion of dermoid cysts, anechoic cysts, or cysts with high risk of malignancy; Age <18 or >45 years; Endometrioma size <30 mm or >100 mm; Ca125 >300 UI/mL; HE4 >70 pM; Pregnant women; Patients who do not wish to participate in the study or who are mentally incapacitated.