Studies how forward bending of the trunk affects airway protection in Parkinson's
Studies how a forward-bent posture affects cough and swallowing in people with Parkinson's disease.
Plain-language title generated from the registry record
Registry title: Effect of Trunk Flexion on Airway Defense in Parkinson's Disease
Key facts
- Where
- Prague, CzechiaSee the site
Where in Czechia
- General University HospitalPrague, CzechiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- General University Hospital, Prague
- Trial code
- NCT06955377
- Record updated
- 2 May 2025
- Original description
The main mechanisms of airway protection include a properly functioning swallowing process and a cough. Studies focusing on patients with Parkinson's disease (PD) have previously demonstrated impairments in both swallowing (dysphagia) and coughing (dystussia). Aspiration pneumonia is the leading cause of death in individuals with PD.Read full original descriptionShow less
Effect of Forward Trunk Flexion in Patients With Parkinson's Disease on the Airway Defense System
The main mechanisms of airway protection include a properly functioning swallowing process and a cough. Studies focusing on patients with Parkinson's disease (PD) have previously demonstrated impairments in both swallowing (dysphagia) and coughing (dystussia). Aspiration pneumonia is the leading cause of death in individuals with PD.
Swallowing function is directly related to body posture. Postural abnormalities (PA) are a common symptom of PD and significantly contribute to patient disability, affect respiratory function, and reduce quality of life. Previous research has shown that more than 20% of PD patients suffer from some form of PA.
Most PD patients with a forward trunk flexion angle greater than 30 degrees report specific difficulties, such as dysphagia. A link has previously been demonstrated between postural abnormalities associated with flexed posture and restrictive ventilatory impairment. It can be assumed that this restrictive ventilatory impairment, which reduces the amount of air the patient can inhale into the lungs and subsequently exhale, negatively affects the strength of voluntary cough. However, this hypothesis has not yet been verified in the mentioned patient group.
The primary aim of the study will be to examine the effect of forward trunk flexion (FTF) in Parkinson's disease on the airway defense system.
Inclusion: Diagnosis of Parkinson' s disease; Age ≥ 18 years.
Exclusion: Other severe neurological diseases apart from PD; History of unstable cardiovascular disease; Severe pulmonary disease; Unreliable performance of MIP, MEP, or grip strength measurements, for example, due to cognitive deficits (assessed by the researcher); Inadequate lip seal; Significant deformities of the dominant hand that could affect the accuracy of grip strength measurements.