Finding Early Brain Lesions in Multiple Sclerosis With a Special MRI
Compares a special MRI scan with standard scans in people with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI
Key facts
- Where
- Banhā and Cairo, EgyptSee the 3 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 15 and 65 years old?
Source: NCT06955832, who can take part
Where in Egypt
- Banha University HospitalsBanhā, EgyptTaking people
- El Mounira Multiple Sclerosis UnitCairo, EgyptTaking people
- Naser Institute MS UnitCairo, EgyptTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Benha University
- Trial code
- NCT06955832
- Record updated
- 18 May 2025
- Original description
The goal of this observational study is to compare the diagnostic accuracy of Phase-Sensitive Inversion Recovery (PSIR) MRI versus conventional T2-weighted (T2W) and Fluid Attenuated Inversion Recovery (FLAIR) sequences in detecting early brain lesions in patients with Multiple Sclerosis (MS). The study will include male and female participants aged 15-65 years diagnosed with MS per the 2017 McDonald criteria.Read full original descriptionShow less
Early Identification of Brain Lesions in Multiple Sclerosis With Phase Sensitive Inversion Recovery MRI: A Cross-sectional Study
The goal of this observational study is to compare the diagnostic accuracy of Phase-Sensitive Inversion Recovery (PSIR) MRI versus conventional T2-weighted (T2W) and Fluid Attenuated Inversion Recovery (FLAIR) sequences in detecting early brain lesions in patients with Multiple Sclerosis (MS). The study will include male and female participants aged 15-65 years diagnosed with MS per the 2017 McDonald criteria.
This study hypothesizes that:
* PSIR MRI will detect a significantly higher number of cortical lesions (intracortical, leukocortical, and juxtacortical) compared to conventional T2W and FLAIR sequences in MS patients (p < 0.05). * Lesions identified exclusively by PSIR will correlate more strongly with clinical measures (EDSS disability scores and SDMT cognitive performance) than those detected by T2W/FLAIR alone, suggesting PSIR's superior sensitivity to clinically relevant pathology.
Inclusion: Age between 15-65 years; Both sexes; Patients with MS according to McDonald Criterion.
Exclusion: Patients with stroke or previous intracranial hemorrhage; Age less than 15 years old; Contraindications to MRI scans; MS mimics.