Not yet recruitingNo phase

Analysis of Risk Factors for Hearing Loss in Survivors of Cancer Occurred During Childhood, Adolescence or Young Adulthood

Key facts

Who runs it: Gustave Roussy, Cancer Campus, Grand Paris
Where: France3 sites in 1 countryChoose a country to see its sites
Trial code: NCT06957132
Status: Not yet recruiting
People taking part: 500 people, planned
Started: May 2025
Planned end: Apr 2026
Type of study: Interventional
Treatments tested: Audiogram
Record updated: 4 May 2025

Who can take part

Age: 18 years to 50 years
Sex: Women and men
Healthy volunteers: Cannot take part

The registry criteria, word for word

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Who can take part

Patients aged between 18 and 50 years at audiological investigations
Treated for brain tumor, solid cancer, lymphoma or leukemia in childhood, adolescence or at a young adult age (<25years)
With at least 5 years of cancer-free follow-up after childhood cancer
Patients included in the FCCSS ( https://fccss.fr ) deep cohort of 7670 5-year childhood cancer survivors treated before 2001, or patients who have planned visit in long-term follow-up clinics of Curie Institute and Gustave Roussy, whatever the diagnostic period
Pregnant or breast-feeding women can be included as no risk is identified
With Social security coverage
Signed written informed consent obtained; NB: Patients included in another research project are not excluded from this one; NB: patients wearing a Lyric hearing prosthesis or any other permanent hearing prosthesis or cochlear implant can be included in the study but will not perform audiological examinations because the audiogram can't be easily performed without hearing prosthesis. Nevertheless, these patients could participate to the study with self-administered questionnaires and could be included as cases (i.e. patients with hearing deficiency) in analyses

Who cannot take part

Patient with unavailable data concerning treatment modalities including cumulative doses of chemotherapy agents or radiation fields and dose
Patient under guardianship or deprived of his liberty by a judicial or administrative decision or incapable of giving its consent

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

Are you between 18 and 50 years old?

This trial has no sites in United States.

It has sites in one country. Choose a country to see its sites.

About the trial

What the trial wants to find out

This study is aimed at people treated for cancer before the age of 25, who have been followed for at least 5 years, and who are now aged between 18 and 50. It is a prospective, multicenter, non-randomized study.

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The main aim of the project is to identify hearing impaired patients using the iAudiogram medical device, and to analyze the risk factors associated with the risk of hearing impairment.

Around 500 patients will take part in this study in France. Participation in this research project will consist in carrying out a hearing test (audiogram with tonal audiometry) with the iAudigram medical device (at Gustave Roussy, Curie or Necker Hospital) and completing self-questionnaires focusing on ototoxicity and its consequences.