Registry collecting spinal fluid and records from patients with antibody-linked brain disorders
Collects spinal fluid samples and clinical records from people with brain disorders.
Plain-language title generated from the registry record
Registry title: Neuroimmunology Registry and Biobank
Key facts
- Where
- Berlin and Ulm, GermanySee the 2 sites
Where in Germany
- Charité Universitätsmedizin BerlinBerlin, GermanyTaking people
- Universität UlmUlm, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Charite University, Berlin, Germany
- Trial code
- NCT06958341
- Record updated
- 6 May 2025
- Original description
A variety of antineuronal antibodies have been detected in the cerebrospinal fluid (CSF) of patients with neurological diseases. This raises the question of whether these antibodies are disease-specific or merely an epiphenomenon of inflammatory processes in the brain.Read full original descriptionShow less
Registry for Patients With Antibody-mediated Neuroimmunological Diseases
A variety of antineuronal antibodies have been detected in the cerebrospinal fluid (CSF) of patients with neurological diseases. This raises the question of whether these antibodies are disease-specific or merely an epiphenomenon of inflammatory processes in the brain.
The registry was established with the following objectives: [1] Are antineuronal antibodies much more common than previously thought in various neurological disorders for which the etiology has not yet been elucidated? [2] Can further correlations, such as those between HSV infection and NMDA receptor autoimmunity, be identified? [3] Are these antibodies mainly non-specific epiphenomena or are they crucial for the pathogenesis? [4] What is the clinical course of patients with antineuronal antibodies and their response to therapy? These questions will be addressed in a broad immunohistological screening of a large number of CSF samples and a clinical database of patients with neurological disorders.
Inclusion: Differential diagnosis: suspected neuroimmunological disease in which a lumbar puncture is indicated for further diagnosis and treatment decision; Individuals with unclear clinical diagnosis where additional CSF is to be collected for isolation of B cells and production of monoclonal antibodies. The clinical condition of the patients and his/her compliance have to allow an extra 2-3 ml of CSF to be collected; Age: all age groups; Gender: patients of both sexes will be included.
Exclusion: [1] Withdrawal of consent.