Studying Why T4 Colon Cancer Comes Back Near Its Original Site
Looks at fluid and blood samples to study recurrence in adults with T4 colon cancer.
Plain-language title generated from the registry record
Registry title: A Translational Study for Locoregional Recurrence of T4 Colon Cancer
Key facts
- Where
- Hsinchu, TaiwanSee the site
Where in Taiwan
- National Taiwan University Hospital Hsin Chu BranchHsinchu, TaiwanTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Taiwan University Hospital
- Trial code
- NCT06958926
- Record updated
- 25 May 2025
- Original description
The outcome of T4 locally advanced colon cancer is poor when locoregional recurrence occurred. Previous studies had showed that the aggravation of T4 colon cancer is higher than N-positive colon cancer, contributing to staging paradox that outcomes of stage IIB/C are poorer than stage IIIA colon cancer and higher locoregional recurrence of stage IIB/C colon cancer. The phenomenon cannot be explained by radicality, lymph node harvested and adjuvant chemotherapy administration. To elucidate the cancerous aggravation of T4 colon cancer, the investigators should dive into the clinicopathology, metastatic mechanism and cancer biology.Read full original descriptionShow less
A Translational Study for Locoregional Recurrence of T4 Colon Cancer
The outcome of T4 locally advanced colon cancer is poor when locoregional recurrence occurred. Previous studies had showed that the aggravation of T4 colon cancer is higher than N-positive colon cancer, contributing to staging paradox that outcomes of stage IIB/C are poorer than stage IIIA colon cancer and higher locoregional recurrence of stage IIB/C colon cancer. The phenomenon cannot be explained by radicality, lymph node harvested and adjuvant chemotherapy administration. To elucidate the cancerous aggravation of T4 colon cancer, the investigators should dive into the clinicopathology, metastatic mechanism and cancer biology.
The investigators hypothesize that peritoneal spreading can be one of the metastatic routes of T4 colon cancer; however, few studies have addressed the finding and deserved investigation. Previous research have found that serum epigenetic alterations and cell-free DNA can serve as a prognostic marker for stage II/III colon cancer.
Therefore, the aim of this study is (1) to explore the role of ascites cfDNA as a potential biomolecular marker for locoregional recurrence; (2) to identify the risk factors of locoregional recurrence for T4 colon cancer by correlating biomolecular markers between clinicopathology, epigenomic alterations in blood and ascites.
Inclusion Criteria:; Age ≥ 18 years old; Diagnosed as colorectal cancer; Undergo radical colectomy or palliative colectomy, not limited to minimally invasive surgery or open surgery; Exclusion Criteria:; Age<18 years old; Pregnancy; Patients with peritoneal dialysis; Patients who are unwilling to undergo colorectal surgery.