NCT06960993Recruiting
Mosaic Trial for Stem Cell Transplant Recipients
Mosaic: RCT of a Digital Health Intervention for English- and Spanish-speaking Stem Cell Transplant Recipients
Source: ClinicalTrials.gov · Last updated 30 Oct 2026
Brief summary (registry, in English)
The goal of this clinical trial is to learn if using an intervention website (Mosaic) improves selected patient-reported outcomes in adult blood cancer patients undergoing allogeneic or autologous stem cell transplant, compared to using an educational website (control group). Patients will be recruited prior to their scheduled transplant, then randomized to use one of these two study websites throughout the study. They will complete five assessments during the study: one before transplant (baseline) and four after transplant (2, 4, 6, and 8 month follow-ups). The main questions this trial aims to answer are: 1. Compared to patients using the control group website, do patients using the intervention website report greater improvements in general psychological distress, cancer treatment-related distress, physical symptoms, and health-related quality of life? 2. Are these benefits at least partially explained by improvements in perceived preparedness, self-efficacy, and approach coping and/or reductions in avoidant coping and perceived stress? 3. Do some patients benefit more from using the intervention website than others? Specifically, we will examine whether patients' primary language (English/Spanish) and their initial psychological distress are related to the benefit they get from using the intervention website. We will also explore effects of sex, race, ethnicity, and transplant type.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 356 (estimated)
- First submitted
- 29 Apr 2025
- Start date
- 28 Apr 2025
- Primary completion date
- 12 Jun 2028
- Lead sponsor
- Northwestern University
- NCT number
- NCT06960993
What you commit to
- Study type: Interventional
- Planned participants: 356
- From 28 Apr 2025 to the primary completion date, 12 Jun 2028
- 3 sites in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- Undergoing the first in a planned tandem stem cell transplant
Other illness
- Unable to provide meaningful consent (severe cognitive impairment or language difficulties)
Other
- Currently participating in a behavioral intervention targeting distress, health-related quality of life, or symptoms
Who the study is looking for
- Diagnosed with a hematologic cancer according to medical records
- Scheduled for or preparing for scheduling of an allogeneic or autologous stem cell transplant at one of our study sites
- Aged 18 or older (no upper limit)
- English or Spanish Proficient
- Interested in using a website to learn about stem cell transplant
- Ability to understand and willingness to sign an informed consent document and comply with all study procedures
Age in the registry: 18 years to - · Sex: All · Does not accept healthy volunteers
Sites (3)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| Northwestern University Feinberg School of Medicine Coordinator of this site? Confirm its status | Chicago | United States | Recruiting |
| Hackensack Meridian Health Coordinator of this site? Confirm its status | Nutley | United States | Recruiting |
| Georgetown University School of Medicine Coordinator of this site? Confirm its status | Washington D.C. | United States | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.