Comparing two heart ablation procedures for persistent atrial fibrillation
Compares two heart ablation procedures in adults with persistent atrial fibrillation.
Plain-language title generated from the registry record
Registry title: Posterior Mitral Isthmus Line With Vein of Marshall Ethanolisation Compared With Anterior Mitral Lines in Patients With Persistent Atrial Fibrillation
Key facts
- Where
- Bruges, BelgiumSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT06962176, who can take part
Where in Belgium
- Az Sint-Jan Brugge AvBruges, BelgiumTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- AZ Sint-Jan AV
- Trial code
- NCT06962176
- Record updated
- 26 October 2026
- Original description
The goal of this clinical study is to find out which treatment works best for people with persistent atrial fibrillation (a type of irregular heartbeat). Researchers are comparing two types of heart ablation procedures:Read full original descriptionShow less
Posterior Mitral Isthmus Line With Vein of Marshall Ethanolisation Compared With Anterior Mitral Lines in Patients With Persistent Atrial Fibrillation
The goal of this clinical study is to find out which treatment works best for people with persistent atrial fibrillation (a type of irregular heartbeat). Researchers are comparing two types of heart ablation procedures:
* An anterior mitral line ablation (a treatment at the front part of the heart) * A posterior mitral line ablation (at the back of the heart), sometimes with an extra step using a small vein called the Vein of Marshall
The main questions the study aims to answer are:
* Which approach works better at fixing the heart rhythm? * Which approach is safer (less complications)?
People who take part in this study will:
* Undergo an ablation procedure as part of their standard care * Attend follow-up visits at 1, 3, and 6 months * Have tests like ECGs, heart ultrasound (echocardiogram), blood tests, heart rhythm monitors (Holter), and a heart CT scan
Inclusion: Patients between the ages of 18 and 80 years, diagnosed with symptomatic persistent AF with clinical indication for left atrial ablation with a mitral isthmus line. Pulmonary vein will be isolated in all patients before starting the mitral isthmus line (during a previous or the same procedure).
Exclusion: Previous mitral line or any other left atrial ablation beyond pulmonary vein isolation; Cardiac surgery within the previous 90 days; Percutaneous transluminal coronary angioplasty/stenting or myocardial infarction within the previous 30 days; Documented history of a thromboembolic event within the previous 60 days; Expecting cardiac transplantation or other cardiac surgery within 180 days; Significant restrictive, constrictive, or chronic obstructive pulmonary disease with chronic symptoms; Acute illness or active infection at time of index procedure; Renal insufficiency; Unstable angina; History of blood clotting or bleeding abnormalities; Uncontrolled heart failure; Presence of a condition that precludes vascular access; Left ventricular ejection fraction <25%; International normalised ratio (INR) greater than 4 within 24 hours of procedure - for patients taking warfarin; Left atrial (LA) thrombus. LA thrombus can be determined by preprocedural imaging: CT, transesophageal echocardiography or MRI; LA diameter greater than 60 mm on long axis parasternal view, or left atrial volume more than 250 cc; Diagnosed atrial myxoma; Significant congenital anomaly or medical problem that in the opinion of the investigator would preclude enrollment; Women who are pregnant or who plan to become pregnant during the study; Contraindication to anticoagulation; Life expectancy less than 1 year; Unwilling or unable to provide informed consent.