Multiprofen-CC to Reduce Pain in Hand Arthritis
Key facts
- Phase
- Phase 3
This trial has no sites in United States.
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Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- St. Joseph's Healthcare Hamilton
- Trial code
- NCT06966206
- Record updated
- 4 May 2026
- Original description
This clinical trial aims to find out if using 1 gram of Multiprofen-CC cream on the hands three times a day for 4 weeks can help reduce pain in adults with hand osteoarthritis, compared to a placebo (a cream with no active medicine). The research team will also look at how Multiprofen-CC affects hand function, opioid use, and how patients feel about their overall improvement. In addition, the research team will keep track of any side effects.Read full original descriptionShow less
Multiprofen-CC to Reduce Pain in Hand Arthritis (MRP-HAND): A Crossover Randomized Controlled Trial
This clinical trial aims to find out if using 1 gram of Multiprofen-CC cream on the hands three times a day for 4 weeks can help reduce pain in adults with hand osteoarthritis, compared to a placebo (a cream with no active medicine). The research team will also look at how Multiprofen-CC affects hand function, opioid use, and how patients feel about their overall improvement. In addition, the research team will keep track of any side effects.
Participants will:
* Use both Multiprofen-CC and a placebo (a cream with no active medicine) during the study, in a random order. * Be asked to apply 1 gram of cream to their hands three times a day for 2 weeks, following the manufacturer's instructions. * Attend a visit before starting the study, after 2 weeks, and after 6 weeks. * Report any symptoms they experience during the study.
Inclusion: Adults (18+); Have been diagnosed with hand osteoarthritis according to American College of Rheumatology criteria; Experience pain and/or loss of function in one or both hands that interferes with daily life; Provide informed consent.
Exclusion: Hand surgery within the past 6 months or planned within the study period; Known allergy or contraindication to any of the study drugs or their ingredients; Have open wounds/cuts and/or skin conditions on the hand area; History of impaired kidney or liver function; Use daily opioids (other than short acting codeine) for a chronic pain condition other than hand arthritis; Unable to consent; Unable or unwilling to follow study protocol; Pregnant or breastfeeding; Rheumatoid or other inflammatory arthropathy.