Airway device with high-flow oxygen during painless gastroscopy in people with obesity
Tests a nasal airway with high-flow oxygen to prevent low oxygen in adults with obesity.
Plain-language title generated from the registry record
Registry title: Nasopharyngeal Airway Combined With Nasal High-flow Oxygen Therapy During Painless Gastroscopy in Obesity Patients
Key facts
- Where
- Nanjing, ChinaSee the site
Where in China
- Nanjing First HospitalNanjing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Nanjing First Hospital, Nanjing Medical University
- Trial code
- NCT06966934
- Record updated
- 22 July 2025
- Original description
Gastroscopy is a commonly used, direct, and reliable method for screening and diagnosing digestive tract diseases. However, as an invasive examination, it can cause adverse reactions such as pain, nausea, vomiting, and choking cough in patients. Compared with ordinary gastroscopy, painless gastroscopy offers higher comfort and satisfaction for patients and greater convenience for endoscopists during operation.Read full original descriptionShow less
The Application of Nasopharyngeal Airway Combined With Nasal High-flow Oxygen Therapy During Painless Gastroscopy in Patients With Obesity
Gastroscopy is a commonly used, direct, and reliable method for screening and diagnosing digestive tract diseases. However, as an invasive examination, it can cause adverse reactions such as pain, nausea, vomiting, and choking cough in patients. Compared with ordinary gastroscopy, painless gastroscopy offers higher comfort and satisfaction for patients and greater convenience for endoscopists during operation.
The most common complication of painless gastroscopy diagnosis and treatment is hypoxia. High-flow nasal cannulala (HFNC) provides a higher oxygen concentration and flow rate than an ordinary nasal catheter. It has the functions of heating and humidifying, which can relieve the pressure on the nasal mucosa cilia, keep the airway unobstructed and moist, and reduce the risk of epistaxis. Due to changes in airway anatomical structures such as fat accumulation in the head and neck and hyperplasia of oropharyngeal soft tissues, obese patients are more prone to hypoxia during gastroscopy under sedation. Therefore, HFNC is often used to reduce the occurrence of hypoxia.
The nasopharyngeal airway (NPA) is used to maintain the patency of the upper respiratory tract and is suitable for patients with spontaneous breathing but partial obstruction of the upper respiratory tract. It is worth exploring how effective the combination of HFNC and NPA is in improving hypoxemia in obese patients during sedation.
Inclusion: Patients undergoing painless gastroscopy; Patients with an age greater than 18 years old; American Society of Anesthesiologists (ASA) physical status classification from Grade I to Grade III; Body Mass Index (BMI) greater than 28 kg/m².
Exclusion: Patients allergic to propofol, eggs, soybeans, milk, etc; Patients with gastrointestinal tract obstruction and gastric emptying disorders; Patients with acute pharyngitis, tonsillitis, and upper respiratory tract infections; Patients in the acute exacerbation stage of respiratory diseases such as asthma, bronchitis, and chronic obstructive pulmonary disease (COPD); Patients with acute arrhythmia and those with severe heart diseases (congenital diseases, valvular diseases); Patients with severe hepatic and renal insufficiency who require alternative treatment; Patients with severe mental disorders who need medications to control their symptoms; Patients with moderate or above anemia, abnormal coagulation function, and hematological diseases; Patients with contraindications to endoscopic procedures or those who refuse sedation/anesthesia; Patients with nasal cavity lesions leading to severe nasal congestion; Pregnant and lactating patients.