Tests brain stimulation for memory problems in people with multiple sclerosis
Tests personalized brain electrical stimulation on thinking problems in people with demyelinating disease.
Plain-language title generated from the registry record
Registry title: Effectiveness of Personalized Alternating Current Stimulation for Treating Cognitive Impairment in CNS Demyelination Patients
Key facts
- Where
- Beijing, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT06968039, who can take part
Where in China
- Xuanwu Hospital, Capital Medical UniversityBeijing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Xuanwu Hospital, Beijing
- Trial code
- NCT06968039
- Record updated
- 13 May 2025
- Original description
Background: Central nervous system inflammatory demyelinating diseases often lead to significant cognitive impairment, presenting a critical challenge in patient management.Read full original descriptionShow less
This Study is Designed to Evaluate the Efficacy of Personalized Alternating Current Stimulation in the Treatment of Working Memory in Patients With Inflammatory Demyelination of the Central Nervous System
Background: Central nervous system inflammatory demyelinating diseases often lead to significant cognitive impairment, presenting a critical challenge in patient management.
Objective: To evaluate the effectiveness of individualized transcranial electrical stimulation (tES) in improving cognitive function among patients with inflammatory demyelinating disorders.
Methods: This study will assess cognitive performance through standardized neuropsychological assessments before and after individualized a one-time tES intervention, measuring changes in cognitive domains including working memory, attention, executive function, and processing speed.
Anticipated Results: We hypothesize that personalized transcranial electrical stimulation will demonstrate significant improvements in cognitive performance, potentially offering a non-invasive therapeutic approach for managing cognitive decline in central nervous system inflammatory demyelinating diseases.
Significance: This research may provide novel insights into neuromodulation strategies for cognitive rehabilitation in patients with complex neurological conditions.
Inclusion: Patients with Neuromyelitis Optica Spectrum Disorders (NMOSD), Multiple Sclerosis (MS), and other Central Nervous System Inflammatory Demyelinating Diseases that meet diagnostic criteria; Patients with SDMT scores <55 or subjective cognitive decline; Age between 18 and 65 years, gender unrestricted; No relapse or medication changes in the past month; EDSS (Expanded Disability Status Scale) score ≤6; Right-handed, native Chinese speakers with sufficient educational background to understand the test instructions; -Willing to participate and have signed informed consent.-.
Exclusion: Medication adjustment within the past month or having undergone modified electroconvulsive therapy, transcranial magnetic stimulation, or other neuromodulation techniques; Participating in any other clinical research within 1 month prior to enrollment or currently; Scoring ≥3 on item 3 (suicide item) of the HDRS-17 or concurrent severe mental illness; Concurrent severe or unstable organic diseases; Presence of cochlear hearing aids, cardiac pacemakers, or implanted brain stimulation devices; Skin integrity damage at electrode placement sites, or allergy to electrode gel or adhesives; History of epilepsy, hydrocephalus, central nervous system tumors, brain injury, or intracranial infections; Relapse record within the past month; Pregnant or lactating women, or those planning pregnancy in the near future; Unable to cooperate with treatment, follow-up, or clinical, EEG, and imaging data collection due to poor patient compliance; Other situations deemed inappropriate for study participation by the researchers.