Magnetic Stimulation with Speech Therapy for Stroke-Related Language Loss
Tests magnetic brain stimulation plus speech therapy in adults with aphasia after recent stroke.
Plain-language title generated from the registry record
Registry title: Transcranial Magnetic Stimulation + Language Therapy to Treat Subacute Aphasia
Key facts
- Where
- Philadelphia, United StatesSee the site
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT06968663, who can take part
Where in United States
- University of PennsylvaniaPhiladelphia, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University of Pennsylvania
- Trial code
- NCT06968663
- Record updated
- 18 June 2026
- Original description
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute stage after stroke.Read full original descriptionShow less
Electrical Field Guided Transcranial Magnetic Stimulation to Treat Subacute Post-stroke Aphasia
The goal of this clinical trial is to determine if Transcranial Magnetic Stimulation (TMS) combined with modified Constraint Induced Language Therapy (mCILT) is an effective treatment for aphasia when delivered in the subacute stage after stroke.
The main questions this study aims to answer are:
1. Can TMS combined with mCILT improve overall speech? 2. Can we identify specific behavioral and biological characteristics that would benefit most from the TMS and mCILT treatment?
Researchers will compare real TMS to sham (fake) TMS to see whether TMS can treat subacute aphasia.
Importantly, this trial will use electric field guided TMS to identify optimal and individualized stimulation intensity and site targeting.
Participants will:
* Complete a screening and medical intake to determine eligibility * Undergo MRI scans * Participate in 10 consecutive sessions (Monday-Friday) of TMS and mCILT treatment * Complete follow-up assessments immediately and 4 months after treatment
Inclusion: Left hemisphere stroke resulting in aphasia; The stroke must have occurred between 2 and 6 weeks prior to enrollment; Must be able to understand the nature of the study, and give informed consent; English proficiency; Right-handed.
Exclusion: Previous head trauma with loss of consciousness for more than 5 minutes; History of serious and/or ongoing issues with substance abuse; History of major psychiatric illness; Dementia, or other neurological conditions; Epilepsy, or seizure after the stroke event; Pacemaker; Diagnosis of tinnitus; Pregnancy.