Frontlight ResearchEarly access
Taking people in United StatesPhase 3
Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery
Key facts
- Who runs it
- Washington University School of Medicine
- Where
- St Louis, United StatesSee the site
- Trial code
- Status
- Recruiting
- Phase
- Phase 3
- People taking part
- 46 people, planned
- Started
- 6 Apr 2026
- Expected to end
- 1 Apr 2028
- Type of study
- Interventional, 2 groupsOne group gets a placebo (a dummy treatment), for comparison.
- Treatments tested
- Fluvoxamine
- Placebo
- Record updated
- 29 April 2026
Who can take part
- Age
- 60 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- English-speaking
- elective non-cardiac or non-intracranial surgery requiring at least a 2-day hospital length of stay
Who cannot take part
- Received investigational drug within the last 7 weeks
- prior known intolerance or allergy to SSRIs or fluvoxamine
- drug or alcohol dependence
- preoperative use of non-NSAID medications with drug-drug interactions of Class X (Avoid Combination) or D (Consider Therapy Modification)
- risk of serotonin syndrome (St John's Wort, SSRIs, or TCA)
- lack of capacity to provide informed consent
- planned postoperative ventilation
Where in United States
- Washington University School of Medicine/Barnes-Jewish HospitalSt Louis, United StatesContact: Sarah KnarrTaking people
About the trial
What the trial wants to find out
The investigation will establish biological plausibility and infrastructure required for a multisite clinical trial evaluating the re-purposing of fluvoxamine to mitigate postoperative delirium risk in geriatric patients undergoing non-cardiac non-intracranial surgery.
The 2 groups in the trial
- FluvoxamineTreatment being tested
100 mg of fluvoxamine on the morning of surgery (POD 0), 100 mg on the evening of surgery (POD 0), 100 mg on the morning of POD 1, and 100 mg on the evening of POD 1. All administered as PO capsules.
- PlaceboPlacebo, for comparison
Placebo capsule on the morning of surgery (POD 0), Placebo capsule on the evening of surgery (POD 0), Placebo capsule on the morning of POD 1, and Placebo capsule on the evening of POD 1. All administered PO.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Mitigating Delirium With Fluvoxamine Treatment for Non-Cardiac Surgery (MD FluNCS)
- Record updated
- 29 April 2026