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Tests a PET scan for measuring kidney filtration around partial kidney removal

Tests a PET scan for kidney filtration in adults with kidney tumors.

Key facts

Who runs it
Luo Yaping
Where
Beijing, ChinaSee the site
Trial code
Registry title
The Study on the Effectiveness of [68Ga]Ga-HBED-CC-DiAsp PET/CT in Calculating GFR and Predicting Residual Renal Function After Partial Nephrectomy
Status
Not yet recruiting
People taking part
40 people, planned
Started
1 Jul 2025
Planned end
10 Nov 2025
Type of study
Interventional, 2 groups
Treatments tested
  • GFR will be measured using three methods at two weeks before surgery and four ± one week after surgery
  • GFR will be measured using three methods: [68Ga]Ga-HBED-CC-DiAsp PET/CT, the Gates method, and the dual plasma sampling method with 99mTc-DTPA.
Record updated
15 May 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults to measure kidney function (GFR) with a PET/CT scan. It includes people with different kidney function and patients planning partial kidney surgery for a tumor.

Age
Older than 18 years; the record lists a maximum age of 88 years.
Sex
All sexes can join.

Main reasons for not taking part

  • Fear of closed spaces (claustrophobia) or fear of radiation
  • Women planning to conceive, pregnant, or breastfeeding
  • Cannot lie flat for 30 minutes
  • Patients or family members who cannot understand the study conditions and goals, or who refuse to take part

The registry criteria, word for word

Show all 6 criteriaShow less

Who can take part

  • Age > 18 years
  • Written informed consent obtained

Who cannot take part

  • Patients with claustrophobia or fear of radiation
  • Patients or family members who cannot understand the conditions and objectives of the study, or who refuse to participate
  • Women who are planning to conceive, pregnant, or breastfeeding
  • Patients unable to lie flat for 30 minutes

Check if you might fit

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 88 years old?

Where in China

  • Peking Union Medical College HospitalBeijing, ChinaContact: Jiayue LiNo longer taking part

About the trial

What the trial wants to find out

In subjects with different levels of renal function and no history of renal tumors, GFR is measured using [68Ga]Ga-HBED-CC-DiAsp PET/CT, the Gates method, and the 99mTc-DTPA dual plasma method. The consistency between the three methods is analyzed using intra-class correlation coefficient (ICC), concordance correlation coefficient (CCC), and Bland-Altman analysis.

Read full original descriptionShow less

In patients scheduled for partial nephrectomy due to renal tumors, GFR is measured using the three methods within 2 weeks before surgery and 4±1 weeks post-surgery. The percentage of postoperative residual renal function (postoperative GFR/preoperative GFR × 100%, hereafter referred to as RRF%) is calculated for each method. By comparing and overlaying preoperative and postoperative PET/CT images, the resected renal area can be delineated on the preoperative PET/CT image. Based on the preoperative PET/CT and the delineated surgical area, a predictive value for postoperative GFR is calculated to obtain the predicted RRF%. A consistency analysis is then performed between the predicted RRF% and the actual RRF% measured by the three methods, using ICC, CCC, and Bland-Altman analysis to evaluate the efficacy of [68Ga]Ga-HBED-CC-DiAsp PET/CT in predicting residual renal function after partial nephrectomy.

The 2 groups in the trial

  • Patients planned for partial nephrectomy due to renal tumorsOther group

    Treatment: GFR will be measured using three methods at two weeks before surgery and four ± one week after surgery

  • Subjects with varying levels of renal function and no history of renal tumorsOther group

    Treatment: GFR will be measured using three methods: [68Ga]Ga-HBED-CC-DiAsp PET/CT, the Gates method, and the dual plasma sampling method with 99mTc-DTPA.

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
The Study on the Effectiveness of [68Ga]Ga-HBED-CC-DiAsp PET/CT in Calculating Glomerular Filtration Rate and Predicting Residual Renal Function After Partial Nephrectomy
Plain-language title
Tests a PET scan for measuring kidney filtration around partial kidney removalGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Fit questions
Built from NCT06973798, who can take part
Record updated
15 May 2025