Brain Imaging Study of Brain Activity in People With Epilepsy
Uses brain scans to study how epilepsy changes brain activity in adults with epilepsy.
Plain-language title generated from the registry record
Registry title: PET/MRI/EEG Imaging Study in Epilepsy
Key facts
- Where
- Charlestown, United StatesSee the site
Where in United States
- Athinoula A. Martinos CenterCharlestown, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Massachusetts General Hospital
- Trial code
- NCT06974305
- Record updated
- 28 October 2026
- Original description
This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography [FDG-PET], and blood flow, measured by functional magnetic resonance imaging [fMRI]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography [EEG]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.Read full original descriptionShow less
Investigation of Interictal Metabolic and Electrophysiologic Changes in Epilepsy Through Trimodal Neuroimaging
This study aims to better understand how epilepsy alters brain function through neuroimaging of healthy people and people with epilepsy. The study investigates how changes in brain metabolism (sugar consumption, measured by positron emission tomography [FDG-PET], and blood flow, measured by functional magnetic resonance imaging [fMRI]) relate to abnormal interictal electrical activity associated with epilepsy (measured by electroencephalography [EEG]). The study will also compare how the three imaging modalities localize regions of abnormal function in the brain.
Inclusion: Age 18 or older; Additional Inclusion Criteria for Subjects with Epilepsy:; Diagnosed with epilepsy with abnormal interictal EEG.
Exclusion: Current use of drugs that modulate brain function; History of severe brain disease such as stroke and head trauma; History of brain surgery; History of type I or II diabetes mellitus; Current or past history of major medical, neurological, or psychiatric conditions; Fasting plasma glucose level >200 mg/dL; Contraindications to PET, MRI, or EEG imaging; Employed under direct supervision of the PI conducting the research; Additional Exclusion Criteria for Healthy Subjects:.