Tests RO7837195 against placebo in moderate to severe ulcerative colitis
Tests RO7837195 against placebo in adults with active ulcerative colitis.
Plain-language title generated from the registry record
Registry title: A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Key facts
- Where
- Camperdown, Murdoch, Parkville VIC, and South Brisbane, AustraliaSee the 4 sites
- Phase
- Phase 2
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with moderately to severely active ulcerative colitis. Earlier treatment with standard or advanced therapies must not have worked well enough.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Moderately to severely active ulcerative colitis (assessed by mMS), diagnosed at least 3 months ago
- Earlier treatment
- Earlier treatment with conventional or advanced therapies for UC did not work well enough, stopped working, or was not tolerated
Main reasons for not taking part
- Prior extensive colon surgery, subtotal or total colectomy, or planned UC surgery
- Crohn's disease or indeterminate colitis
- Earlier treatment with an advanced therapy targeted at tumor necrosis factor-like cytokine 1A (TL1a)
- Treatment with an advanced therapy targeted at IL-12 and/or IL-23 that did not work well enough, stopped working, or was not tolerated
Read by machine on 9 November 2026.
Where in Australia
- Royal Prince Alfred HospitalCamperdown, AustraliaTaking people
- Fiona Stanley HospitalMurdoch, AustraliaTaking people
- Royal Melbourne HospitalParkville VIC, AustraliaTaking people
- Mater Misericordiae LimitedSouth Brisbane, AustraliaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Genentech, Inc.
- Trial code
- NCT06979336EU 2025-520690-39-00
- Record updated
- 27 October 2026
- Original description
The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventional and/or advanced therapies has failed.Read full original descriptionShow less
A Phase IIb, Multicenter, Double-blind, Placebo-controlled Induction Study With an Active Treatment Extension to Assess the Efficacy, Safety, and Pharmacokinetics of RO7837195 in Patients With Moderately to Severely Active Ulcerative Colitis
The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventional and/or advanced therapies has failed.
Inclusion: Diagnosis of ulcerative colitis (UC) established at least 3 months; Moderately to severely active UC assessed by mMS; Inadequate response, loss of response, or intolerance to conventional or advanced therapies for UC.
Exclusion: Prior extensive colonic resection, subtotal or total colectomy, or planned surgery for UC; Treatment with an advanced therapy targeted at tumor necrosis factor-like cytokine 1A (TL1a); Inadequate response, loss of response, or intolerance to treatment of UC with an advanced therapy targeted at IL-12 and/or IL-23; Diagnosis of Crohn's disease or indeterminate colitis.