Tests RO7837195 against placebo in moderate to severe ulcerative colitis
Tests RO7837195 against placebo in adults with active ulcerative colitis.
Plain-language title generated from the registry record
Registry title: A Study to Evaluate the Efficacy, Safety, and Pharmacokinetics (PK) of RO7837195 in Participants With Moderately to Severely Active Ulcerative Colitis (UC)
Key facts
- Where
- Bydgoszcz, Chojnice, Cracow, Grudziadz, Katowice, Knurów, Nowy Targ, Opole, Poznan, Skierniewice, Szczecin, Warsaw, Wroclaw, and Zamość, PolandSee the 25 sites
- Phase
- Phase 2
Where in Poland
- Manermed Sp. z o.o.Bydgoszcz, PolandTaking people
- Osrodek Badan Klinicznych Clinsante S.C. Ewa Galczak-Nowak MalgorzataBydgoszcz, PolandTaking people
- Centrum Medyczne LukaMed Joanna ŁukaChojnice, PolandTaking people
- Centrum Medyczne Plejady Magdalena Celinska Loewenhoff Michal Zolnowski sp.k.Cracow, PolandTaking people
- Centrum Medyczne Clw-Med Aneta Cichomska I Joanna Luka-Wendrowska Sp. j.Grudziadz, PolandTaking people
- Vita Longa Sp. Z o.o.Katowice, PolandTaking people
- MZ Badania Slowik Zymla Sp.j.Knurów, PolandTaking people
- Allmedica Badania Kliniczne Sp z o.o. Sp K.Nowy Targ, PolandTaking people
- Twoja Przychodnia Opolskie Centrum MedyczneOpole, PolandTaking people
- Clinical Research Center Sp z o o Medic R Sp kPoznan, PolandTaking people
- EMC Instytut Medyczny S.A.Poznan, PolandTaking people
- Solumed Centrum Medyczne Sp. z o.o.Poznan, PolandTaking people
- Termedia Sp. z o.o.Poznan, PolandTaking people
- Twoja Przychodnia Poznanskie Centrum Medyczne Sp. z o.o.Poznan, PolandTaking people
- Velocity Skierniewice Sp. z o.o.Skierniewice, PolandTaking people
- Twoja Przychodnia-Szczecinskie Centrum Medyczne Sp. z o. o.Szczecin, PolandTaking people
- Eb Group Sp. z o.o.Warsaw, PolandTaking people
- Medical Network Sp z o oWarsaw, PolandTaking people
- Medon Clinical Research Sp. z o.o.Warsaw, PolandTaking people
- Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i AdministracjiWarsaw, PolandTaking people
- Provita Poliklinika sp. z o.oWarsaw, PolandTaking people
- Wsd Medi Clinical Sp. z o.o.Warsaw, PolandTaking people
- Centrum Medyczne OporowWroclaw, PolandTaking people
- Vistamed & Vertigo Sp Z O OWroclaw, PolandTaking people
- Etg Zamosc Sp. z o.o.Zamość, PolandTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Genentech, Inc.
- Trial code
- NCT06979336EU 2025-520690-39-00
- Record updated
- 27 October 2026
- Original description
The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventional and/or advanced therapies has failed.Read full original descriptionShow less
A Phase IIb, Multicenter, Double-blind, Placebo-controlled Induction Study With an Active Treatment Extension to Assess the Efficacy, Safety, and Pharmacokinetics of RO7837195 in Patients With Moderately to Severely Active Ulcerative Colitis
The purpose of this study is to evaluate the efficacy of RO7837195 compared with placebo in participants with moderately to severely active ulcerative colitis for whom prior treatment with conventional and/or advanced therapies has failed.
Inclusion: Diagnosis of ulcerative colitis (UC) established at least 3 months; Moderately to severely active UC assessed by mMS; Inadequate response, loss of response, or intolerance to conventional or advanced therapies for UC.
Exclusion: Prior extensive colonic resection, subtotal or total colectomy, or planned surgery for UC; Treatment with an advanced therapy targeted at tumor necrosis factor-like cytokine 1A (TL1a); Inadequate response, loss of response, or intolerance to treatment of UC with an advanced therapy targeted at IL-12 and/or IL-23; Diagnosis of Crohn's disease or indeterminate colitis.