Using a new ultrasound to study blood vessels in bladder cancer
Checks bladder cancer blood vessels with a new ultrasound during surgery in 30 adults.
Key facts
- Who runs it
- Duke University
- Where
- Durham, United StatesSee the site
- Trial code
- Registry title
- Characterizing the Microvascular Environment of Bladder Cancer With Super-Resolution Ultrasound Localization Microscopy
- Status
- Recruiting
- People taking part
- 30 people, planned
- Started
- 28 Oct 2025
- Expected to end
- Apr 2027
- Type of study
- Observational
- Record updated
- 4 May 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with bladder cancer (urothelial cancer) who are having the whole bladder removed. A new ultrasound is done before surgery.
- Age
- Over 18 years
- Sex
- All sexes can join.
- Disease stage
- Proven urothelial bladder cancer where the treating doctor advises removal of the bladder, such as muscle-invasive disease or high-risk non-muscle-invasive disease (for example high-grade T1 not responding to BCG, or worrisome cell variants).
Main reasons for not taking part
- Known or suspected allergy to sulfur hexafluoride lipid microsphere or its parts, such as polyethylene glycol (PEG)
- Pregnant or breastfeeding
- Serious allergic reaction to a COVID-19 vaccination
- Unstable condition, such as hospital in-patients, ICU patients, or high-risk heart disease
- Declines to take part
The registry criteria, word for word
Show all 7 criteriaShow less
Who can take part
- Adults > 18 years
- Histological evidence of urothelial cancer of the bladder for which radical cystectomy is recommended as per the treating physician (e.g., MIBC or high-risk NMIBC, such as high-grade T1 BCG refractory and worrisome histological variants)
Who cannot take part
- Known or suspected hypersensitivity to sulfur hexafluoride lipid microsphere or its components, such as polyethylene glycol (PEG)
- Participants who had serious allergic reactions to COVID-19 vaccination
- Participants with unstable conditions such as hospital in-patients, ICU patients, or high-risk cardiac diseases
- Pregnancy or breastfeeding
- Decline to participate in the study
Where in United States
- Duke UniversityDurham, United StatesContact: Alireza Ghoreifinejadian, M.D.Taking people
About the trial
What the trial wants to find out
The project will include 30 patients with bladder cancer who are candidates for bladder removal. After signing the consent form, the study team will collect some clinical data, such as age, past medical history, past surgical history, and information about your current disease.
Read full original descriptionShow less
At the day of surgery, after putting participants into sleep and before surgery begins, the study team will do a novel ultrasound called "Super-Resolution Ultrasound Localization Microscopy" to check if there is still disease in the bladder. The team will then compare the results of this investigational ultrasound with the final pathology and other imaging studies.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Characterizing the Microvascular Environment of Bladder Cancer With Super-Resolution Ultrasound Localization Microscopy
- Plain-language title
- Using a new ultrasound to study blood vessels in bladder cancerGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 4 May 2026