New MRI Scans for Finding Bone Damage in Multiple Myeloma
Tests new whole-body MRI scans to detect bone lesions in adults with myeloma.
Plain-language title generated from the registry record
Registry title: "Pseudo-scanner" MRI Sequences for the Detection of Bone Lesions in Multiple Myeloma
Key facts
- Where
- Brussels, BelgiumSee the site
Where in Belgium
- Cliniques universitaires Saint-LucBrussels, BelgiumTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
- Trial code
- NCT06988020
- Record updated
- 24 April 2026
- Original description
Recent work has confirmed the diagnostic performance of pseudo-CT sequences for detecting osteolytic lesions. Their integration into whole body MRI (WB MRI) could transform the diagnostic approach to MM, by allowing a combined assessment of bone marrow involvement, tissue viability and osteolysis, during a single non-irradiating imaging examination. Since the preliminary work mentioned above, optimizations have been made to the pseudo-CT sequences, including the addition of deep learning (correcting noise in the images) and the correction of chemical shift artifact (linked to the coexistence of hydrated tissue and fatty tissue), which carry real hope of improving their diagnostic potential and accuracy.Read full original descriptionShow less
Evaluation of Optimised Whole-body MRI Examinations Incorporating "Pseudo-scanner" Sequences (ZTE, "Zero Echo Time" AND Lava Flex) for the Detection of Bone Lesions in Multiple Myeloma
Recent work has confirmed the diagnostic performance of pseudo-CT sequences for detecting osteolytic lesions. Their integration into whole body MRI (WB MRI) could transform the diagnostic approach to MM, by allowing a combined assessment of bone marrow involvement, tissue viability and osteolysis, during a single non-irradiating imaging examination. Since the preliminary work mentioned above, optimizations have been made to the pseudo-CT sequences, including the addition of deep learning (correcting noise in the images) and the correction of chemical shift artifact (linked to the coexistence of hydrated tissue and fatty tissue), which carry real hope of improving their diagnostic potential and accuracy.
Inclusion: Patient with newly diagnosed multiple myeloma, for whom bone imaging is required for staging; Recurrent patient after intensive treatment (high dose chemotherapy, bone marrow transplant, etc.); Patient requiring a PET / CT considered as the technique of choice in these stages of the disease.
Exclusion: Implanted material incompatible with MRI; Severe claustrophobia; Pregnant women.