Tests a yoga-based movement device in people with Alzheimer's disease or memory decline
Tests a yoga-based breathing and movement device in adults with Alzheimer's or mild memory impairment.
Plain-language title generated from the registry record
Registry title: Yoga-based, Movement Therapy Device as Noninvasive Glymphatic Clearance Augmentation in Alzheimer's Disease.
Key facts
- Where
- Bratislava, SlovakiaSee the site
Where in Slovakia
- AuraMedica s.r.o., Neurologická ambulancia, OMNIA BUSINESS CENTER, Tomášikova 19081/28CBratislava, SlovakiaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- CIATRIX, INC.
- Trial code
- NCT06989242
- Record updated
- 10 July 2025
- Original description
This clinical trial evaluates a yoga-based intervention delivered through a powered therapeutic device designed to guide breathing and body movements. Building on evidence that mind-body practices may promote healthy aging, cognitive function, and glymphatic flow, the study uses physiological measurements, including fNIRS and wearable sensors, to investigate mechanisms and potential benefits in individuals at risk for Alzheimer's disease.Read full original descriptionShow less
Yoga-based, Movement Therapy Device as Noninvasive Glymphatic Clearance Augmentation in Alzheimer's Disease. The Feasibility and Safety Trial With Preliminary Clinical, Digital, and Fluid Biomarker Proxies of Glymphatic Clearance
This clinical trial evaluates a yoga-based intervention delivered through a powered therapeutic device designed to guide breathing and body movements. Building on evidence that mind-body practices may promote healthy aging, cognitive function, and glymphatic flow, the study uses physiological measurements, including fNIRS and wearable sensors, to investigate mechanisms and potential benefits in individuals at risk for Alzheimer's disease.
Inclusion: 55-85 years of age; Current diagnostic criteria for stage 3 AD patients (AD-MCI); Current diagnostic criteria for stage 4 AD patients (mAD); Able to provide consent to be in the study; Willing and able to participate in study activities; Able to lay supine for 30-45 minutes; Able to walk 20 meters; Willing to not perform additional mind-body practices during the duration of the study; Able to use a wearable electronic device (Smart watch).
Exclusion: Regular use of muscle relaxants or anti-anxiety drugs; Any muscle or skeletal issues that would make it difficult to lie still in the supine position for the 1-hour physical therapy; Spinal injuries, clinically relevant disc herniation, spinal stenosis, spondylolisthesis in the sacral, lumbar, thoracic, or cervical spine, spinal bifida, Recent Spinal Surgery; Craniospinal disorders, e.g., Chiari Malformation; History of neurological disorders such as stroke (during the last year before study start), mild brain injury within past 6 months, multiple sclerosis, presence of intracranial hemorrhage, hydrocephalus, meningitis, encephalitis, brain tumor (except of asymptomatic meningioma GI); Serious sleep disorders - narcolepsy; Major or uncontrolled psychiatric illness or major depression; Any condition requiring the use of medication that acts on the brain such as stimulants, sedatives (hypnotics and benzodiazepines), antipsychotics, and anti-anxiety medications, (we will include patients with stable antidepressant treatment and being on mild anti-seizure medication due to polyneuropathy); Active infection or uncontrolled significant systemic illnesses; Asthma, chronic obstructive pulmonary disease; Recent hearth attack, Implantable defibrillator, poorly controlled blood pressure cardiac arrhythmia, unstable angina pectoris, or symptomatic congestive heart failure; People at risk of blood clots or deep vein thrombosis (DVT) might want to avoid prolonged sitting in the chair; Inability to provide informed consent; Severe osteoporosis with a risk of fracture; Obesity over 135 kg (300lb); Smoking more than 5 cigarettes a day or drinking more than 1 alcoholic beverage a day.