Studies bladder bacteria in men with bladder cancer, benign urinary disease and healthy men
Compares urinary bacteria in men with bladder cancer, benign urinary disease and healthy men.
Plain-language title generated from the registry record
Registry title: Urinary Microbiome Differences in Bladder Cancer, Benign Urinary Diseases and Healthy Counterparts in Adult Male Population
Key facts
- Where
- Rome, ItalySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for men aged 50 to 70 in three groups: men with bladder cancer, men with benign urinary diseases, and healthy men. It compares the bladder microbiome between the groups.
- Age
- 50 to 70 years
- Sex
- Men only
- Disease stage
- Bladder cancer group: urothelial carcinoma confirmed by tissue examination, with radical cystectomy planned. Benign group: renal cysts, benign prostatic obstruction, or ureteropelvic or ureteral obstruction needing surgery.
- Earlier treatment
- Bladder cancer group: no previous BCG therapy and no previous neoadjuvant therapy. No antibiotic treatment within two months before joining.
- Biomarker or test result
- Bladder cancer group: negative urine culture.
Main reasons for not taking part
- Other neoplasias (bladder cancer group)
- Indwelling catheter (bladder cancer group)
- History of sexually transmitted diseases (bladder cancer group)
- Chronic intestinal inflammation (bladder cancer group)
- Diabetes, chronic kidney disease, cardiac disease or hepatic disease (healthy group)
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 50 and 70 years old?
Source: NCT06992986, who can take part
Where in Italy
- Regina Elena National Cancer InstituteRome, ItalyContact: Giuseppe Simone, DoctorTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Regina Elena Cancer Institute
- Trial code
- NCT06992986
- Record updated
- 28 May 2025
- Original description
The study aims to investigate alterations in the bladder microbiome in adult men with bladder cancer, healthy men, and men with benign urinary diseaseRead full original descriptionShow less
Urinary Microbiome Differences in Bladder Cancer, Benign Urinary Diseases and Healthy Counterpars Adult Male Population: a Pilot Study
The study aims to investigate alterations in the bladder microbiome in adult men with bladder cancer, healthy men, and men with benign urinary disease
Inclusion: Diagnosis of bladder cancer; Negative urine culture; Histological confirmation of urothelial carcinoma; Patients undergoing radical cystectomy; Controls will be collected from men within the specified age range. Eligible controls may be drawn from the institution's personnel attending the occupational medicine department or in service in the Institute; -To ensure that alterations in the microbiome observed in bladder cancer patients are unique to this condition, an additional group with benign urinary diseases will be included in the analysis. This group will encompass individuals with renal cysts, benign prostatic obstruction, ureteropelvic or ureteral obstruction undergoing surgical therapy.
Exclusion: History of previous BCG therapy; Active antibiotic treatment with two months prior to participation; Previous neoadyuvant therapy; History of sexual transmitted diseases; Diabetes; Chronic Kidney Disease; Cardiac disease; Hepatic disease; Presence of other neoplasias; Use of indwelling catheter; Presence of chronic intestinal inflammation; NA.