EEG Evaluation of CBT for Obsessive-Compulsive Disorder
Key facts
- Who runs it
- Uskudar University
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Active, not recruiting
- People taking part
- 60 people enrolled
- Started
- 1 Jan 2025
- Ended
- 25 Oct 2025
- Type of study
- Interventional, 2 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- Cognitive Behavioral Therapy (CBT)
- Record updated
- 3 June 2025
Who can take part
- Age
- 18 years to 65 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Aged between 18 and 65 years
- Diagnosed with Obsessive-Compulsive Disorder (OCD) according to DSM-5 criteria
- Yale-Brown Obsessive Compulsive Scale (Y-BOCS) total score ≥16
- Not currently receiving psychiatric medication (at least 2-week washout required)
- No psychotherapy (including CBT) in the past 6 months
- Willing and able to participate in EEG procedures
- Capable of providing written informed consent
Who cannot take part
- Prior CBT treatment for OCD within the past 6 months
- Use of any psychiatric medication in the past 2 weeks
- History of epilepsy, head trauma, or neurological disorders
- Current diagnosis of schizophrenia, bipolar disorder, or substance use disorder
- Severe physical illness or unstable medical condition
- Pregnancy or breastfeeding
- Currently participating in another clinical trial
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This clinical trial investigates how Cognitive Behavioral Therapy (CBT), a psychological treatment that helps people change their thought and behavior patterns, affects brain function in people diagnosed with Obsessive-Compulsive Disorder (OCD). OCD is characterized by repeated, unwanted thoughts (obsessions) and behaviors (compulsions) that significantly interfere with daily life.
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Although CBT is known to effectively reduce OCD symptoms, exactly how it changes brain activity remains unclear. This study aims to measure the effects of CBT on brain function using electroencephalography (EEG), a safe, non-invasive way to monitor brain activity.
Participants diagnosed with OCD will be randomly assigned to two groups. One group will receive CBT consisting of 12 individual therapy sessions, held weekly, lasting about 50 minutes each. The other group will not receive therapy during the study but will be offered treatment afterward. Brain activity and psychological well-being will be measured three times: before starting treatment, immediately after completing CBT, and again three months later.
By comparing these two groups, the study hopes to answer whether CBT causes measurable changes in brain activity and how these changes relate to improvements in OCD symptoms. Results from this study could help improve future treatments and understanding of OCD.
The 2 groups in the trial
- CBT Intervention GroupTreatment being tested
Participants receive 12 weekly individual Cognitive Behavioral Therapy (CBT) sessions, each session lasting approximately 50 minutes. CBT includes Exposure and Response Prevention (ERP), cognitive restructuring, psychoeducation, and relapse prevention strategies.
Treatment: Cognitive Behavioral Therapy (CBT)
- Waiting List ControlNo study treatment, for comparison
Participants receive no intervention during the 12-week treatment period but are offered CBT treatment after the completion of the study.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Neurophysiological Effects of Cognitive Behavioral Therapy in the Treatment of Obsessive-Compulsive Disorder: An EEG Clinical Study
- Publications
- Record updated
- 3 June 2025