Studies regional anesthesia for painful crises in people with sickle cell disease
Observes whether regional nerve-block pain relief changes inflammation in adults with sickle cell crises.
Plain-language title generated from the registry record
Registry title: Impact of Regional Anesthesia on Inflammatory Mechanisms During Vaso-occlusive Crisis in Sickle Cell Patients
Key facts
- Where
- Pointe-à-Pitre, GuadeloupeSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with sickle cell disease who are having a vaso-occlusive crisis (a painful blockage of blood flow). It studies regional anesthesia during the crisis.
- Age
- Over 18 years (minimum age 18 years)
- Sex
- All sexes can join.
- Disease stage
- Currently in a vaso-occlusive crisis from sickle cell disease.
- Earlier treatment
- No blood transfusion within the last 3 months.
Main reasons for not taking part
- Pregnant or breastfeeding women
- Blood transfusion within the last 3 months
- Not affiliated with the French social security system
- Protected individuals
Read by machine on 9 November 2026.
Where in Guadeloupe
- CHU de la GuadeloupePointe-à-Pitre, GuadeloupeTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Centre Hospitalier Universitaire de la Guadeloupe
- Trial code
- NCT07001189
- Record updated
- 3 June 2025
- Original description
Sickle cell disease is a chronic disease characterized by multiple vaso-occlusive complications. The basic treatment for patients with a vaso-occlusive crisis (VOC) is based on adequate hydration, oxygen therapy and pain control. Loco Regional Anesthesia (LRA) is one of the major treatments in resuscitation anesthesia for both anesthesia and analgesia. LRA allows effective and almost immediate pain control by blocking nerve afferents in a given area. LRA could decrease the inflammatory response during crises and accelerate resolution of the crisis.Read full original descriptionShow less
Impact of Regional Anesthesia on Inflammatory Mechanisms During Vaso-occlusive Crisis in Sickle Cell Patients
Sickle cell disease is a chronic disease characterized by multiple vaso-occlusive complications. The basic treatment for patients with a vaso-occlusive crisis (VOC) is based on adequate hydration, oxygen therapy and pain control. Loco Regional Anesthesia (LRA) is one of the major treatments in resuscitation anesthesia for both anesthesia and analgesia. LRA allows effective and almost immediate pain control by blocking nerve afferents in a given area. LRA could decrease the inflammatory response during crises and accelerate resolution of the crisis.
Inclusion: patients adult >18 years; patients with vaso-occlusive crisis.
Exclusion: Pregnant or breastfeeding women; Blood transfusion within the last 3 months; Lack of affiliation with the French social security system; Protected individuals.