Diaphragm Ultrasound and Muscle Signal Testing in Sleep Apnea and COPD
Compares diaphragm ultrasound and muscle signal testing in adults with sleep apnea, COPD, or both.
Plain-language title generated from the registry record
Registry title: Diaphragmatic Function and Respiratory Drive in OSA and COPD
Key facts
- Where
- Nanjing, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with obstructive sleep apnea, with COPD, or with both, and also healthy volunteers. It compares how the diaphragm works in each group.
- Age
- 18 to 80 years
- Sex
- All sexes can join
- Disease stage
- Obstructive sleep apnea group: AHI of 5 events/hour or more on an overnight sleep study. COPD group: COPD diagnosed by GOLD guidelines. Overlap group: both conditions. Control group: no known breathing disease or sleep disorder.
Main reasons for not taking part
- Severe heart disease (for example unstable angina or heart failure NYHA III/IV)
- Severe liver or kidney failure
- Nerve or muscle disease affecting breathing muscles
- Upper airway or chest surgery within the last 3 months
- Pregnancy or breastfeeding
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07003399, who can take part
Where in China
- The First Affiliated Hospital of Nanjing Medical UniversityNanjing, ChinaContact: Ding Ning, doctorTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Nanjing Medical University
- Trial code
- NCT07003399
- Record updated
- 25 June 2025
- Original description
This cross-sectional observational study aims to assess the diaphragmatic morphofunction and respiratory drive characteristics among patients with obstructive sleep apnea (OSA), chronic obstructive pulmonary disease (COPD), overlap syndrome (OS), and healthy controls. Using ultrasound imaging and surface diaphragm electromyography (EMGdi), the study will explore group differences in diaphragmatic morphology, function, and respiratory drive indicators, and evaluate their clinical significance in disease differentiation and severity assessment.Read full original descriptionShow less
Diaphragmatic Morphofunction and Respiratory Drive in OSA and COPD: Insights From Ultrasound and EMG-based Cross-Sectional Analysis
This cross-sectional observational study aims to assess the diaphragmatic morphofunction and respiratory drive characteristics among patients with obstructive sleep apnea (OSA), chronic obstructive pulmonary disease (COPD), overlap syndrome (OS), and healthy controls. Using ultrasound imaging and surface diaphragm electromyography (EMGdi), the study will explore group differences in diaphragmatic morphology, function, and respiratory drive indicators, and evaluate their clinical significance in disease differentiation and severity assessment.
Inclusion: Patients aged between 18 and 80 years; For OSA Group: Diagnosed obstructive sleep apnea with AHI ≥ 5 events/hour based on overnight polysomnography; For COPD Group: Diagnosed chronic obstructive pulmonary disease based on GOLD guidelines; For Overlap Group: Diagnosed both OSA (AHI ≥ 5) and COPD; For Control Group: Healthy volunteers with no known respiratory diseases or sleep disorders; Ability and willingness to provide informed consent for participation in the study.
Exclusion: Recent upper airway or thoracic surgery (within 3 months); Severe cardiovascular diseases (e.g., unstable angina, heart failure NYHA III/IV); Severe hepatic or renal insufficiency; Neuromuscular diseases affecting respiratory muscles; Participants who cannot complete assessments due to cognitive impairment or poor cooperation; Pregnancy or breastfeeding.