Compares Purinostat with selinexor in relapsed diffuse large B-cell lymphoma
Tests Purinostat against selinexor in adults with returned or resistant large B-cell lymphoma.
Plain-language title generated from the registry record
Registry title: A Phase III Clinical Study of Purinostat Mesylate for Injection in Patients With Diffuse Large B-cell Lymphoma
Key facts
- Where
- Chengdu, ChinaSee the site
- Phase
- Phase 3
Where in China
- West China Hospital，Sichuan UniversityChengdu, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Chengdu Zenitar Biomedical Technology Co., Ltd
- Trial code
- NCT07011056
- Record updated
- 19 September 2025
- Original description
The main objective of this study is to evaluate the differences in objective response rate and overall survival between the Purinostat mesylate for injection and selinexor, as assessed by blinded independent central review (BICR), in patients with relapsed or refractory diffuse large B-cell lymphoma.Read full original descriptionShow less
A Randomized, Controlled, Multicenter Phase III Clinical Study Evaluating the Efficacy and Safety of the Purinostat Mesylate for Injection (PM) Compared to Selinexor in Patients With Relapsed/Refractory Diffuse Large B-cell Lymphoma (R/R DLBCL)
The main objective of this study is to evaluate the differences in objective response rate and overall survival between the Purinostat mesylate for injection and selinexor, as assessed by blinded independent central review (BICR), in patients with relapsed or refractory diffuse large B-cell lymphoma.
.The participants in the experimental group will receive treatment with Purinostat mesylate for injection. The dosage is 11.2 mg/m2. Each administration cycle consists of intravenous administration on days 1, 4, 8, and 11. A 21-day period constitutes one treatment cycle, and the total treatment cycle lasts for 6 cycles.
.Participants in the control group will receive selinexor treatment. The recommended dose is 60 mg per dose, taken orally on days 1 and 3 of each week (for example, Monday and Wednesday, or Tuesday and Thursday), and a 4-week period constitutes one treatment cycle.
Inclusion: Age ≥ 18 years, no gender restrictions; Histologically-confirmed DLBCL, Participants must have relapsed or failed to respond to at least two lines of prior systemic therapy (2-5 lines); Participants must have measurable disease; ECOG≤2; Adequate organ function.
Exclusion: Previous history of transplantation; Patient with known active infection, or reactivation of a latent infection; Any serious diseases that investigator deems inappropriate to participate; Pregnancy or breastfeeding; Double/Triple Hit B cell lymphoma.