Precision Analytic Research Methods in OCD
Key facts
- Who runs it
- Icahn School of Medicine at Mount Sinai
- Where
- New York, United StatesSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 100 people, planned
- Started
- 9 Jul 2025
- Expected to end
- 31 Mar 2030
- Type of study
- Interventional, 2 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- Exposure and Response Prevention
- Record updated
- 2 November 2026
Who can take part
- Age
- 18 years to 55 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Participants must be:
- between the ages 18-55 years old
- English-speaking
- right-handed
- able to provide consent
Who cannot take part
- are taking psychiatric medication or have received behavioral treatment for OCD within a certain timeframe
- they meet diagnostic criteria for certain other psychiatric disorders
- they have a current psychiatric disorder
- a lifetime history of certain psychiatric disorders
- are taking psychiatric medication or have in the past
- Individuals diagnosed with OCD will be excluded if:
- if it is unsafe for them to participate in research; Healthy control participants will be excluded if:
- have a parent or sibling who has been diagnosed with OCD
- if it is unsafe for them to participate in research
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 55 years old?
Where in United States
- Icahn School of Medicine at Mount SinaiNew York, United StatesContact: Amy Rapp (principal investigator)Taking people
About the trial
What the trial wants to find out
Psychiatric disorders characterized by compulsivity, such as obsessive-compulsive disorder (OCD), result in considerable functional impairment and many individuals do not respond to gold-standard treatments. Compulsivity has long been thought to occur due to exaggerated habits and reduced goal-directed control, although more recently, this conceptualization of compulsivity as an imbalance of two cognitive systems has been challenged as overly narrow. This study will recruit 100 individuals (50 adults diagnosed with OCD, 50 healthy controls) and leverage the measurement precision offered by theory-driven computational modeling in combination with electroencephalogram (EEG) to go beyond this binary theory of compulsivity, revealing how more complex interactions of neurocognitive subcomponents contribute to compulsivity-information that could ultimately lead to improved treatment personalization and clinical outcomes.
The 2 groups in the trial
- Participants diagnosed with OCDTreatment being tested
All participants diagnosed with Obsessive Compulsive Disorder (OCD) who enroll in this study will receive 17 sessions of exposure and response prevention, a specialized cognitive behavioral therapy for OCD, over the course of 10 weeks.
Treatment: Exposure and Response Prevention
- Healthy controlsNo study treatment, for comparison
Individuals who do not have a current or lifetime psychiatric diagnosis will not receive any treatment.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Dissecting Neurocognitive Components of Compulsivity Using Computational Modeling and EEG
- Fit questions
- Built from NCT07011901, who can take part
- Record updated
- 2 November 2026