Studies how childhood adversity relates to multiple sclerosis
Studies childhood hardship and its effects on multiple sclerosis in young adults.
Plain-language title generated from the registry record
Registry title: Care in Multiple Sclerosis (MS)
Key facts
- Where
- Aurora, Birmingham, Boston, Cleveland, Houston, and San Francisco, United StatesSee the 6 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 29 years old?
Source: NCT07011914, who can take part
Where in United States
- University of Colorado DenverAurora, United StatesTaking people
- University of Alabama at BirminghamBirmingham, United StatesTaking people
- Massachusetts General HospitalBoston, United StatesTaking people
- Cleveland ClinicCleveland, United StatesTaking people
- Baylor College of MedicineHouston, United StatesTaking people
- University of California San FranciscoSan Francisco, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- NYU Langone Health
- Trial code
- NCT07011914
- Record updated
- 26 October 2026
- Original description
This study is structured around three main aims.Read full original descriptionShow less
CARE in MS: Childhood Adversity Research Effort in MS
This study is structured around three main aims.
In Aim 1, investigators will conduct community-based participatory research (CBPR) to develop culturally tailored methods to assess childhood adversity in multiple sclerosis (MS).
Aim 2 will investigate the impact of childhood adversity on MS outcomes among individuals with relapsing-remitting MS (RRMS), among whom 70% belong to a group historically under-represented in MS research: Black, Hispanic, or poverty-impacted. Aim 2 procedures involve two visits that include a research blood draw and an MRI scan.
In Aim 3, investigators will conduct interviews and surveys to explore environmental and social factors affecting quality of life for minority MS patients.
Inclusion: Aim 1 -; aged ≥18-29 years; diagnosis of RRMS (Fulfill international criteria for relapsing remitting (RRMS)); 70% self-identifying as a Black, Hispanic, or poverty-impacted (up to 138% of the federal poverty level) individual,and; fluent in English or Spanish; Aim 2 -; aged ≥18-29 years; diagnosis of RRMS (Fulfill international criteria for relapsing remitting (RRMS)); 70% self-identifying as a Black, Hispanic, or poverty impacted, and; fluent reading in English or Spanish; Pediatric onset MS (MS onset before age 18 and age at time of enrollment is 18-25) OR adult-onset MS (MS onset at age 18 or older and age at time of enrollment is 19-29); Disease duration below 8 years; Aim 3 -; Aim 3 will enroll the first 20 participants from Aim 2 who meet the following criteria:; completed at least 80% of study data in the cross-sectional study/Aim 2; a total of 70% must self-identify as Black, Hispanic, or meet criteria for poverty impacted; interviews will be evenly split between participants with high (top quartile) and low (bottom quartile) of PROMIS-10 scores.
Exclusion: MS relapse within 30 days prior to study entry; Other major neurologic or psychiatric illness; Primary or Secondary Progressive MS; Inability to consent.