Studies how kidney nerve stimulation affects people with high blood pressure
Tests kidney nerve stimulation before and after denervation in adults with hypertension.
Plain-language title generated from the registry record
Registry title: Spyral InSight Study
Key facts
- Where
- Athens, GreeceSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 20 and 70 years old?
Source: NCT07013929, who can take part
Where in Greece
- Hippokration General Hospital of AthensAthens, GreeceTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Medtronic Vascular
- Trial code
- NCT07013929
- Record updated
- 20 October 2026
- Original description
The purpose of the Spyral InSight Early Clinical Feasibility Study is to characterize the physiological response to renal nerve stimulation (RNS) in humans prior to and post renal denervation.Read full original descriptionShow less
Spyral InSight Early Clinical Feasibility Study
The purpose of the Spyral InSight Early Clinical Feasibility Study is to characterize the physiological response to renal nerve stimulation (RNS) in humans prior to and post renal denervation.
Inclusion: 20 - 70 years of age; Office SBP ≥150 mmHg and <180 mmHg and DBP ≥90 mmHg; Individual is prescribed with one, two, or three antihypertensive medication classes; 24-hour ABPM average of SBP ≥135 and <170 mmHg at Baseline.
Exclusion: Prior renal denervation; Individual is taking SGLT2 inhibitors or GLP-1 agonists; Individual is currently taking anti-mineralocorticoid drugs; Primary pulmonary hypertension; Secondary cause of hypertension; Individual has a documented condition that would prohibit or interfere with ability to obtain an accurate blood pressure measurement; Individual has an estimated glomerular filtration rate (eGFR) of <60 mL/min/1.73m2; Individual lacks appropriate renal artery Anatomy; Has a renal artery stent; Individual requires chronic oxygen support or mechanical ventilation; Pregnant, nursing or planning to become pregnant during the study.