0.005% Latanoprost Gel for Nonsegmental Vitiligo
Key facts
- Where
- Bandung, IndonesiaSee the site
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 10 and 17 years old?
Source: NCT07016113, who can take part
Where in Indonesia
- Hasan sadikin general hospitalBandung, IndonesiaContact: Safira M Pranata, MDNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Universitas Padjadjaran
- Trial code
- NCT07016113
- Record updated
- 11 June 2025
- Original description
Latanoprost, a prostaglandin F2α (PGF2α) analog used for glaucoma treatment, is known to cause iris darkening, hypertrichosis, and periocular skin hyperpigmentation. PGF2α has been shown to stimulate the growth of melanocyte dendrites, increasing dendricity even at low doses, as well as enhancing tyrosinase activity and quantity, thereby promoting repigmentation. Studies on the use of 0.005% latanoprost gel in both children and adults with vitiligo have demonstrated effective repigmentation without reported side effects.Read full original descriptionShow less
Comparison of the Effectiveness Between a Combination of 0.005% Latanoprost Gel With 308 nm Excimer Phototherapy and a Combination of 0.1% Mometasone Furoate Cream With 308 nm Excimer Phototherapy on Repigmentation of Nonsegmental Vitiligo in Children
Latanoprost, a prostaglandin F2α (PGF2α) analog used for glaucoma treatment, is known to cause iris darkening, hypertrichosis, and periocular skin hyperpigmentation. PGF2α has been shown to stimulate the growth of melanocyte dendrites, increasing dendricity even at low doses, as well as enhancing tyrosinase activity and quantity, thereby promoting repigmentation. Studies on the use of 0.005% latanoprost gel in both children and adults with vitiligo have demonstrated effective repigmentation without reported side effects.
Inclusion: Patients with non-segmental vitiligo; Patients with stable vitiligo for at least 6 months based on the Vitiligo Disease Activity (VIDA) score; Aged 10-17 years; Affected area <10%; Having at least two lesions to be treated. The vitiligo lesions selected for treatment must meet the following criteria:; Relatively the same size, ranging from a minimum of 1 cm² to 4 cm²; Bilateral location on both sides of the body; A minimum distance of 5 cm between the studied lesions and other vitiligo lesions; Not located on the palms, soles, or genital area.
Exclusion: Use of topical therapy (corticosteroids, calcineurin inhibitors, psoralen, and antioxidants) for at least 2 weeks before the study, systemic therapy (corticosteroids, antioxidants, and vitamin D) for at least 4 weeks before the study, and phototherapy for at least 4 weeks before the study; Presence of other active autoimmune diseases such as type 1 diabetes mellitus, thyroid disease, alopecia areata, rheumatoid arthritis, or Addison's disease, based on medical history and physical examination; History of or current skin cancer, photosensitivity, or undergoing radiotherapy; Allergy or contraindication to topical corticosteroids or latanoprost; History of hypertension, asthma, diabetes mellitus, anemia, kidney, liver, neurological, or cardiovascular diseases.