Heart Scan Before Valve Replacement to Check Coronary Arteries
Tests a detailed heart scan in adults with aortic valve narrowing before valve replacement.
Plain-language title generated from the registry record
Registry title: Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha PCD-CT Before TAVI Procedure
Key facts
- Where
- Freiburg im Breisgau, Mainz, and Tübingen, GermanySee the 3 sites
Where in Germany
- Albert-Ludwigs-Universität FreiburgFreiburg im Breisgau, GermanyNot yet recruiting
- University Medical Center MainzMainz, GermanyTaking people
- Universitätsklinikum TübingenTübingen, GermanyNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Semmelweis University
- Trial code
- NCT07016477
- Record updated
- 11 June 2025
- Original description
The clinical and demographic characteristics of patients undergoing transcatheter aortic valve implantation (TAVI) pose unique challenges for coronary computed tomography (CT) imaging, as this patient population is mainly composed of elderly, frail individuals with severe aortic stenosis, multiple comorbidities, high prevalence of heavily calcified coronary artery disease (CAD) and revascularized coronary arteries. Such vulnerable patients could benefit from a more precise assessment and characterization of their CAD with ultra-high resolution (UHR) photon-counting detector (PCD) CT that would potentially avoid the need for pre-implantation invasive coronary angiography (ICA). This international multicenter prospective registry study aims to investigate the feasibility and diagnostic accuracy of PCD-CT in the assessment of CAD in the high-risk population of patients undergoing TAVI, as compared to ICA.Read full original descriptionShow less
Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha Photon Counting-detector CT Before Transcatheter Aortic Valve Implantation
The clinical and demographic characteristics of patients undergoing transcatheter aortic valve implantation (TAVI) pose unique challenges for coronary computed tomography (CT) imaging, as this patient population is mainly composed of elderly, frail individuals with severe aortic stenosis, multiple comorbidities, high prevalence of heavily calcified coronary artery disease (CAD) and revascularized coronary arteries. Such vulnerable patients could benefit from a more precise assessment and characterization of their CAD with ultra-high resolution (UHR) photon-counting detector (PCD) CT that would potentially avoid the need for pre-implantation invasive coronary angiography (ICA). This international multicenter prospective registry study aims to investigate the feasibility and diagnostic accuracy of PCD-CT in the assessment of CAD in the high-risk population of patients undergoing TAVI, as compared to ICA.
Inclusion: Clinically indicated TAVI; Clinically indicated CT and invasive coronary angiography; There are no contraindications to CT angiography; Understanding and signing the consent form.
Exclusion: Any condition for which TAVI is contraindicated and therefore no prior radiological investigation of TAVI is indicated; Chronic renal failure (eGFR <30 ml/m2); Pregnancy or breastfeeding; Active oncological treatment.