Under construction – not a live service
Sign in
Taking peopleNo phase

Heart Scan Before Valve Replacement to Check Coronary Arteries

Tests a detailed heart scan in adults with aortic valve narrowing before valve replacement.

Key facts

Who runs it
Semmelweis University
Where
Zurich, SwitzerlandSee the siteAlso in 4 other countries, 6 sites
Trial code
Registry title
Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha PCD-CT Before TAVI Procedure
Status
Recruiting
People taking part
1,000 people, planned
Started
1 Jun 2024
Expected to end
30 May 2030
Type of study
Observational
Treatments tested
  • Ultra-High Resolution Photon Counting Detector Coronary Computed Tomography Angiography
Record updated
11 June 2025

Who can take part

AI summary

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for adults with severe aortic valve narrowing who are planned for a TAVI heart valve procedure. They also need a heart CT scan and an invasive coronary angiography.

Age
18 years or older
Sex
Women and men can join.
Disease stage
Aortic valve stenosis with TAVI (transcatheter aortic valve implantation) clinically indicated.

Main reasons for not taking part

  • Pregnancy or breastfeeding
  • Chronic kidney failure (eGFR <30 ml/m2)
  • Active cancer treatment
  • Any condition for which TAVI is contraindicated
  • Any contraindication to CT angiography

The registry criteria, word for word

Show all 8 criteriaShow less

Who can take part

  • Clinically indicated TAVI
  • Clinically indicated CT and invasive coronary angiography
  • There are no contraindications to CT angiography
  • Understanding and signing the consent form

Who cannot take part

  • Any condition for which TAVI is contraindicated and therefore no prior radiological investigation of TAVI is indicated
  • Chronic renal failure (eGFR <30 ml/m2)
  • Pregnancy or breastfeeding
  • Active oncological treatment

Where in Switzerland

Also in 4 other countries, 6 sites

  • University Hospital of ZurichZurich, SwitzerlandContact: Hatem Alkadhi, MDNot yet recruiting

About the trial

What the trial wants to find out

The clinical and demographic characteristics of patients undergoing transcatheter aortic valve implantation (TAVI) pose unique challenges for coronary computed tomography (CT) imaging, as this patient population is mainly composed of elderly, frail individuals with severe aortic stenosis, multiple comorbidities, high prevalence of heavily calcified coronary artery disease (CAD) and revascularized coronary arteries. Such vulnerable patients could benefit from a more precise assessment and characterization of their CAD with ultra-high resolution (UHR) photon-counting detector (PCD) CT that would potentially avoid the need for pre-implantation invasive coronary angiography (ICA). This international multicenter prospective registry study aims to investigate the feasibility and diagnostic accuracy of PCD-CT in the assessment of CAD in the high-risk population of patients undergoing TAVI, as compared to ICA.

The group in the trial

  • Aortic stenosis

    Patients with aortic valve disease for whom transcatheter aortic valve implantation is indicated and who present for pre-interventional evaluation will be enrolled after written consent.

    Treatment: Ultra-High Resolution Photon Counting Detector Coronary Computed Tomography Angiography

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Data and sources

Registry record
Listed on ClinicalTrials.gov.
Official title
Prospective Registry of Patients Undergoing Cardiac CT With NAEOTOM Alpha Photon Counting-detector CT Before Transcatheter Aortic Valve Implantation
Plain-language title
Heart Scan Before Valve Replacement to Check Coronary ArteriesGenerated from the registry record. The registry title is the official one.
AI summary
From the trial's eligibility criteria. Read by machine on 12 November 2026.
Record updated
11 June 2025