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Taking people in GabonNo phase

Studies drug-resistant tuberculosis strains spreading in Central Africa

Observes how drug-resistant tuberculosis strains are genetically related and spread in Central Africa.

Plain-language title generated from the registry record
Registry title: Molecular Epidemiology, Strains Genotyping of Multi-drug Resistant Tuberculosis Circulating in Central Africa Region

Key facts

Where
Lambaréné, Libreville, Makokou, Mouila, Oyem, and Port-Gentil, GabonSee the 8 sites

Where in Gabon

  • Centre Hospitalier Régional Georges RawiriLambaréné, GabonTaking people
  • Hôpital Albert SchweitzerLambaréné, GabonTaking people
  • Hôpital de NkemboLibreville, GabonTaking people
  • Centre Hospitalier Régional de MakokouMakokou, GabonTaking people
  • Centre de Traitement Ambulatoire (CTA) de MouilaMouila, GabonTaking people
  • Hôpital de BongoloMouila, GabonTaking people
  • Centre Hospitalier Régional d'OyemOyem, GabonTaking people
  • Centre Hospitalier Régional TchéguéPort-Gentil, GabonTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?
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Trial details

Who runs it
Centre de Recherche Médicale de Lambaréné
Trial code
NCT07017803
Record updated
29 October 2026
Original description
Multidrug-resistant tuberculosis (MDR-TB) poses a significant challenge in Central Africa. Understanding the molecular epidemiology and genotypic characteristics of MDR-TB strains is crucial for effective control measures. This is highlighted by the emergence of mutations encoding resistance to bed aquiline and quinolones which may impact the roll out of the newly recommended Bedaquiline, Pretomanid, Linezolid and Moxifloxacin (BPaLM) regimens. It is also worth noting that there is increasing evidence of the significance of TB lineage in the outcome of infection, the approach in the study will provide both information on chains of transmission and lineage.Read full original descriptionShow less

Molecular Epidemiology, Strains Genotyping of Multi-drug Resistant Tuberculosis Circulating in Central Africa Region

Multidrug-resistant tuberculosis (MDR-TB) poses a significant challenge in Central Africa. Understanding the molecular epidemiology and genotypic characteristics of MDR-TB strains is crucial for effective control measures. This is highlighted by the emergence of mutations encoding resistance to bed aquiline and quinolones which may impact the roll out of the newly recommended Bedaquiline, Pretomanid, Linezolid and Moxifloxacin (BPaLM) regimens. It is also worth noting that there is increasing evidence of the significance of TB lineage in the outcome of infection, the approach in the study will provide both information on chains of transmission and lineage.

Inclusion: All GeneXpert positive TB patients and participants who provide written informed consent will be screened for the study. Participants aged above 8 who can provide sputum will also be screened; Patients enrolled in the tuberculosis epidemiology (TB-EPI) study and eligible for MESTCAR will be enrolled without any additional consent form as the data to be collected for the two studies will be shared and no additional process is needed.

Exclusion: Samples which do not meet the quality criteria; Samples not enough to perform all of the laboratory process; Samples contaminated.

ClinicalTrials.gov NCT07017803