A Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Participants With Graves' Disease
Key facts
- Where
- Dobrich, Plovdiv, Sliven, Smolyan, Sofia, Sofiya, Varna, and Yambol, BulgariaSee the 14 sites
- Phase
- Phase 2
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07018323, who can take part
Where in Bulgaria
- Medical Center Viva Phoenix OODDobrich, BulgariaNo longer taking part
- University Multiprofile Hospital For Active Treatment Kaspela EOODPlovdiv, BulgariaNo longer taking part
- University Multiprofile Hospital For Active Treatment Pulmed Ltd.Plovdiv, BulgariaNo longer taking part
- Multiprofile Hospital For Active Treatment Hadji Dimitar OODSliven, BulgariaNo longer taking part
- Medical Center Smolyan Klinikal Research Ltd.Smolyan, BulgariaNo longer taking part
- Alexandrovska University HospitalSofia, BulgariaNo longer taking part
- Kalimat Medical Center Ltd.Sofia, BulgariaNo longer taking part
- Multiprofile Hospital for Active Treatment "Knyaginya Klementina" - Sofia EADSofia, BulgariaNo longer taking part
- University Specialized Hospital For Active Treatment In Endocrinology Akad. Iv. Penchev EADSofia, BulgariaNo longer taking part
- University Multiprofile Hospital For Active Treatment Sofiamed OODSofiya, BulgariaNo longer taking part
- Diagnostic Consultative Center Equita OODVarna, BulgariaNo longer taking part
- Medcenter Nova Clinic Ltd.Varna, BulgariaNo longer taking part
- Medical Centre "Pratia Clinic" EOODVarna, BulgariaNo longer taking part
- Medical Center Berbatov Ltd.Yambol, BulgariaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Immunovant Sciences GmbH
- Trial code
- NCT07018323EU 2025-521920-31-00
- Record updated
- 30 October 2026
- Original description
This is a multi-center, global, randomized, double-blind, placebo-controlled Phase 2b study to assess the efficacy, safety, and tolerability of IMVT-1402 in adult participants with Graves' disease (GD) who are hyperthyroid despite antithyroid drug (ATD) treatment.Read full original descriptionShow less
A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Assess the Efficacy, Safety, and Tolerability of IMVT-1402 as Treatment for Adult Patients With Graves' Disease
This is a multi-center, global, randomized, double-blind, placebo-controlled Phase 2b study to assess the efficacy, safety, and tolerability of IMVT-1402 in adult participants with Graves' disease (GD) who are hyperthyroid despite antithyroid drug (ATD) treatment.
Inclusion: Participants with the ability to understand the requirements of the trial, provide written informed consent, and comply with the trial protocol procedures; Male or female participants aged ≥ 18 years; Participants with diagnosis of GD who are hyperthyroid despite ATD treatment; Other, more specific inclusion criteria are defined in the protocol.
Exclusion: Have previously been successfully treated with radioactive iodine (RAI) therapy or have undergone total thyroidectomy; Have an autoimmune disease other than GD requiring treatment that, in the Investigator's judgment, puts the participant at undue risk; Have moderate-to-severe active thyroid eye disease (TED) and are expected to require immediate surgical intervention and/or are planning corrective surgery/irradiation or medical therapy for TED during study participation; Additional exclusion criteria are defined in the protocol.