POTS-FLOW: Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS
Key facts
- Where
- Copenhagen, DenmarkSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 50 years old?
Source: NCT07019519, who can take part
Where in Denmark
- RigshospitaletCopenhagen, DenmarkContact: Sophie W Nielsen, MDTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- University of Copenhagen
- Trial code
- NCT07019519
- Record updated
- 13 June 2025
- Original description
This study will describe the interplay between the gut hormones GIP and CCK and their regulation of blood flow to the large vessels in patients with Postural Orthostatic Tachycardia Syndrome (POTS) and GIP, CCK and GLP-1 in healthy. This is addressed by hormone infusions during MR-scans of the abdomen and intake of oral glucose.Read full original descriptionShow less
Interplay Between Gut Hormones and Autonomic Postprandial Blood Flow Regulation in Patients With POTS
This study will describe the interplay between the gut hormones GIP and CCK and their regulation of blood flow to the large vessels in patients with Postural Orthostatic Tachycardia Syndrome (POTS) and GIP, CCK and GLP-1 in healthy. This is addressed by hormone infusions during MR-scans of the abdomen and intake of oral glucose.
Inclusion: Previously diagnosed with POTS in tilt test or active stand-test (either newly diagnosed within last 3 months or in new tilt test/active stand test during screenings visit); Reproducible orthostatic intolerance with raise in HR on >30 bpm when standing within 10 minutes of change of supine to standing in age >19 years or >40 bpm in age 18-19 years; POTS symptoms/orthostatic intolerance; Age 18-50; Waist ratio <180 cm; Age 18-50; Waist ratio <180 cm; Matched a POTS patient in age, sex and BMI.
Exclusion: Metallic implants; Metallic implants; Chronic illness; Other types of sinus tachycardia or heart disease; Thyroid disease or TSH out of reference; Any disease that might influence the health of the participant during the study or participants that receives medicine that cannot be paused for 36 hours; Chronic illness; POTS; other types of sinus tachycardia or heart disease; Thyroid disease or TSH out of reference; Any disease that might influence the health of the participant during the study or participants that receives medicine that cannot be paused for 36 hours; Decreased kidney function eGFR <90 or elevated kreatinkinasis; Decreased kidney function eGFR <90 or elevated kreatinkinasis; Above 10 alcoholic drinks or week or substance abuse; Liverenzymes two times above normal values; Uncontrollable low or high blood pressure; Blood vessels that cannot be visualized on MR; Above 10 alcoholic drinks or week or substance abuse; Liverenzymes two times above normal values; Uncontrollable low or high blood pressure, Orthostatic hypotension; Blood vessels that cannot be visualized on MR.