Studying Risk Factors for Leaks After Pancreas Surgery in Cancer Patients
Looks for factors that predict a pancreatic fistula after pancreaticoduodenectomy surgery in patients with cancer.
Plain-language title generated from the registry record
Registry title: Predictive Risk Factors for Pancreatic Fistula After Pancreaticoduodenectomy
Key facts
- Where
- Minya, EgyptSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 75 years old?
Source: NCT07022015, who can take part
Where in Egypt
- Liver and GIT hospital , Minia UniversityMinya, EgyptTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Minia University
- Trial code
- NCT07022015
- Record updated
- 10 November 2026
- Original description
Pancreaticoduodenectomy (PD) is a complex procedure performed in patients with malignant or benign tumors of the pancreatic head and periampullary region, associated with high morbidity and mortality. Postoperative pancreatic fistula (POPF) is the most common and clinically significant complication following PD. In this study, the investigators aim to determine the predictive risk factors for clinically related postoperative pancreatic fistula (CR-POPF) in the preoperative, intraoperative and postoperative period in patients that underwent PD. The total number of 100 participants expected to be included in this research who underwent PD between 2025 and 2026.Read full original descriptionShow less
Predictive Risk Factors for Postoperative Pancreatic Fistula After Pancreaticoduodenectomy for Malignancy.
Pancreaticoduodenectomy (PD) is a complex procedure performed in patients with malignant or benign tumors of the pancreatic head and periampullary region, associated with high morbidity and mortality. Postoperative pancreatic fistula (POPF) is the most common and clinically significant complication following PD. In this study, the investigators aim to determine the predictive risk factors for clinically related postoperative pancreatic fistula (CR-POPF) in the preoperative, intraoperative and postoperative period in patients that underwent PD. The total number of 100 participants expected to be included in this research who underwent PD between 2025 and 2026.
Inclusion: Patients with resectable distal common bile duct carcinoma, periampullary carcinoma, duodenal carcinoma, and carcinoma of the head of the pancreas; Patients meeting the curative treatment intent in accordance with clinical guidelines:; No evidence of metastasis; Radiological non-involvement of superior mesenteric vein \& portal vein; American Society of Anesthesiologists (ASA) scores I \& II; Patients aged > 18 years; Ability to understand and the willingness to sign a written informed consent document; Agreement to complete the study.
Exclusion: Patients with vascular invasion and requiring vascular resection as evaluated by the multidisciplinary team according to abdominal imaging data; Unfit patients for surgery due to severe medical illness; History of other malignant disease; Patients with serious mental disorders; Inoperable patients with distant metastases, including peritoneal, liver, distant lymph node metastases, and involvement of other organs; Irresectable tumors in diagnostic laparoscopy; Pregnant or breast-feeding women; Pancreatoduodenectomy for other diagnosis like cystic lesions, benign tumors or chronic calcific pancreatitis; Patients refused to participate in the study.