Exercise and Diet Study for Women With Endometrial Cancer Before Surgery
Tests exercise and healthy eating in women with endometrial cancer before surgery.
Plain-language title generated from the registry record
Registry title: Metabolic Effect of Exercise and Diet in Endometrial Cancer Patients Eligible for Staging Surgery.
Key facts
- Where
- México, MexicoSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07025213, who can take part
Where in Mexico
- Instituto Nacional de CancerologiaMéxico, MexicoTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- National Institute of Cancerología
- Trial code
- NCT07025213
- Record updated
- 17 June 2025
- Original description
Background:Read full original descriptionShow less
Metabolic Effect of a Physical Activity and Dietary Intervention, and Its Association With Musculoskeletal Changes, in Endometrial Cancer Patients Eligible for Staging Surgery, Compared to Patients Not Receiving the Physical Activity Intervention. A Pilot Study.
Background:
Endometrial cancer is one of the diseases linked to obesity in women. In Mexico, about 7.6 women out of every 100,000 are diagnosed with this type of cancer, and nearly three-quarters of these women have obesity. Many women with endometrial cancer also have a condition called sarcopenic obesity, where muscle loss happens but might not be easy to identify. Researchers believe that certain molecules in the blood could help identify the health of muscles. Exercise helps muscles stay strong and healthy by affecting these molecules. For women with cancer, staying active can help maintain muscle mass, which is important for better recovery and health outcomes. This project focuses on an exercise program for women with locally advanced endometrial cancer who will be treated surgically at the National Cancer Institute of Mexico (INCan).
What We Think Will Happen:
Women with endometrial cancer who participate in a program combining physical activity and healthy eating will gain more muscle strength and function compared to those who don't exercise. We expect these changes to be connected to healthier levels of certain molecules in the blood, showing less muscle breakdown and less inflammation. We also believe these women will have better control of blood sugar and fats.
Our Main Goal:
To find out how physical activity and diet affect muscle health and metabolism in women with endometrial cancer, and to compare these changes to women who don't participate in the exercise program.
How We Will Do It:
We will measure molecules related to muscle health in the blood. We will also assess muscle size, strength, and how well the muscles work. Then, we will look for connections between these muscle changes and the blood molecules. We want to see if improvements in muscle are linked to better recovery from surgery and better health outcomes. If so, these blood molecules might help doctors monitor muscle health. We hope that the exercise program will help women recover better and improve their quality of life.
How We Will Analyze the Data:
We will describe the data we collect and compare the group that exercises to the group that doesn't. We will use statistics to see if the differences are meaningful. We will also analyze the relationship between muscle health and blood markers. Advanced methods will help us identify which molecules and measurements best explain the changes seen. The results will be carefully reviewed using specialized software.
What We Hope to Find:
We aim to show that blood tests can help identify muscle health and how it improves with exercise. This could lead to earlier detection of muscle loss and better management through exercise programs. Ultimately, this work hopes to improve the health and well-being of women facing endometrial cancer.
Inclusion: -Ability to understand the nature of the study and provide written informed consent; -Women aged over 18 and under 65 years; -Availability to attend exercise sessions; -Willingness and ability to comply with scheduled visits, the proposed nutritional algorithm, treatment plan, and laboratory tests; -Histologically confirmed diagnosis of endometrioid-type endometrial cancer by biopsy; -Normal electrocardiogram (ECG) result; -No prior oncological treatment; -Body mass index (BMI) greater than 20 kg/m²; -Availability of a computed tomography (CT) scan; -Candidates for staging surgery.
Exclusion: -Patients with a prior or concurrent malignancy, except non-melanoma skin cancer; -Patients with concurrent infections; -Patients with advanced clinical stage or stage IVB disease (according to FIGO 2018 criteria); -Patients with uncontrolled systemic arterial hypertension; -Patients with uncontrolled psychiatric disorders, including claustrophobia; -Patients with autoimmune disease; -Patients with neuromuscular disease; -Patients with renal dysfunction (eGFR ≤ 60 mL/min/1.73 m²); -Contraindications to physical exercise; -Vulnerable situations (e.g., homelessness preventing adherence to diet, or incarceration).